Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-TAg)1Efr
• Allele Name: transgene insertion 1, Shimon Efrat
• Allele ID: MGI:3770670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ins2-rtTA)2Efr/0 Tg(tetO-TAg)1Efr/0	involves: C3HeB/FeJ * C57BL/6 * CBA	MGI:3770671

Genotype
MGI:3770671

cx1

• Allelic Composition: Tg(Ins2-rtTA)2Efr/0; Tg(tetO-TAg)1Efr/0
• Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130049 )

N • in presence of doxycycline, strepzotocin-treated mice transplanted with beta cells isolated from insulinomas from double-transgenic mice display euglycemia within one day of transplantation; blood glucose levels remained in euglycemic range for >6 weeks after doxycycline withdrawal

hypoglycemia ( J:130049 )

• mice receiving doxycycline in drinking water to induce transgene expression develop hypoglycemia by 3-4 months of age; mutants not treated with doxycycline remain euglycemic and have normal islet morphology

neoplasm

increased insulinoma incidence ( J:130049 )

• hypoglycemic mice are observed to have multiple insulinomas in pancreas

endocrine/exocrine glands

increased insulinoma incidence ( J:130049 )

• hypoglycemic mice are observed to have multiple insulinomas in pancreas