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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pycardtm1Nnz
targeted mutation 1, Gabriel Nunez
MGI:3771030
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pycardtm1Nnz/Pycardtm1Nnz involves: 129 * C57BL/6 MGI:3771034


Genotype
MGI:3771034
hm1
Allelic
Composition		 Pycardtm1Nnz/Pycardtm1Nnz
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycardtm1Nnz mutation (0 available); any Pycard mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:129871 )
• peritoneal macrophages or dendritic cells fail to secrete IL-1beta in response to Listeria infection
• peritoneal macrophages have reduced secretion of IL-1beta in response to a TLR2 agonist
decreased interleukin-18 secretion ( J:129871 )
• peritoneal macrophages have reduced secretion of IL-1beta in response to a TLR2 agonist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory