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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec14l2tm1Arai
targeted mutation 1, Hiroyuki Arai
MGI:3771069
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sec14l2tm1Arai/Sec14l2tm1Arai involves: 129S7/SvEvBrd MGI:3771072


Genotype
MGI:3771072
hm1
Allelic
Composition		 Sec14l2tm1Arai/Sec14l2tm1Arai
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec14l2tm1Arai mutation (0 available); any Sec14l2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:129749 )
• fasting decreases plasma cholesterol levels 70% compared to wild-type in association with decreased hepatic cholesterol synthesis
• cholesterol levels are decreased by fibrates unlike in wild-type mice
decreased circulating VLDL cholesterol level ( J:129749 )
• VLDL secretion is decreased during fasting compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory