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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nbntm2.1Jpt
targeted mutation 2.1, John H Petrini
MGI:3771078
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nbntm2.1Jpt/Nbntm2.1Jpt involves: 129 MGI:3771143
cx2
 		Lig4tm1Icrf/Lig4tm1Icrf
Nbntm2.1Jpt/Nbntm2.1Jpt 		involves: 129 MGI:3831186
cx3
 		Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt 		involves: 129S6/SvEvTac * 129/Sv MGI:3771170
cx4
 		Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * 129/Sv MGI:3771144
cx5
 		Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt 		involves: 129S7/SvEvBrd * 129/Sv MGI:3771145


Genotype
MGI:3771143
hm1
Allelic
Composition		 Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ionizing radiation ( J:129762 )
• following exposure to 10 Gy, mouse embryonic fibroblast cells exhibit a defect in the intra-S phase checkpoint and only 36% of cells suppress DNA synthesis compared to 51% of wild-type cells
• exposure to ionizing radiation results in a reduction of the apoptotic response in thymus cells compared to wild-type mice exhibit increased apoptosis in the thymus following exposure to ionizing radiation
• however, the distribution of thymocytes is normal




Genotype
MGI:3831186
cx2
Allelic
Composition		 Lig4tm1Icrf/Lig4tm1Icrf
Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Icrf mutation (0 available); any Lig4 mutation (46 available)
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:144172 )
• no live births are observed




Genotype
MGI:3771170
cx3
Allelic
Composition		 Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic
Background		 involves: 129S6/SvEvTac * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (170 available)
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ionizing radiation ( J:129762 )
• cells undergo fail to exhibit increased levels of apoptosis following exposure to ionizing radiation




Genotype
MGI:3771144
cx4
Allelic
Composition		 Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:129762 )
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular
decreased apoptosis ( J:129762 )
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
anemia ( J:129762 )
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced




Genotype
MGI:3771145
cx5
Allelic
Composition		 Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S7/SvEvBrd * 129/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:129762 )
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular
decreased apoptosis ( J:129762 )
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
anemia ( J:129762 )
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory