Analysis Tools
mortality/aging
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• most mice die by P14 with severe weight loss and nearly all mice die by weaning
• however, postnatal lethality can be rescued by intraperitoneal injection of copper
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homeostasis/metabolism
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• copper levels are reduced in the heart, brain, kidney and spleen to 18%, 20%, less than 40% and 70%, respectively, of wild-type levels
• copper levels are over 8-fold higher in intestinal epithelial cells compared to wild-type
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• serum copper levels are less than 40% of wild-type
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• copper content in the liver reduced to 5% of wild-type
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• iron content in the liver is increased 4-fold compared to in wild-type mice
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cardiovascular system
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• cardiac tissue exhibits large vacuoles and swollen mitochondria not present in wild-type cardiac tissue
• however, abnormal cardiac tissue morphology can be partially rescued by intraperitoneal injection of copper
|
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• hearts are enlarged 20% compared to wild-type
• cardiac hypertrophy occurs at 2 weeks of age
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growth/size/body
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• hearts are enlarged 20% compared to wild-type
• cardiac hypertrophy occurs at 2 weeks of age
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• at P14, mice weigh 4 g instead 9 g for wild-type mice
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weight loss
(
J:129741
)
|
• mice die with severe weight loss
• however, postnatal weight lose can be rescued by intraperitoneal injection of copper
|
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• mice exhibit poor growth beginning at day 10
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behavior/neurological
hematopoietic system
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• spleen weight adjusted for decreased body weight is less than in wild-type mice
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pigmentation
liver/biliary system
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• copper content in the liver reduced to 5% of wild-type
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immune system
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• spleen weight adjusted for decreased body weight is less than in wild-type mice
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integument
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• whiskers are kinked and brittle
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loose skin
(
J:129741
)
|
• skin laxity
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