Phenotypes associated with this allele

• Allele Symbol: Pyy^tm1.1Batt
• Allele Name: targeted mutation 1.1, Rachel L Batterham
• Allele ID: MGI:3771165
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pyy^tm1.1Batt/Pyy^tm1.1Batt	involves: C57BL/6 * FVB/N * SJL	MGI:3771168

Genotype
MGI:3771168

hm1

• Allelic Composition: Pyy^tm1.1Batt/Pyy^tm1.1Batt
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

polyphagia ( J:129742 )

• daily food intake and re-feeding in response to overnight feeding are increased

• however, administration of 10 ug/100 g of body weight PYY3-36 is decreased food intake to wild-type levels

• mice are resistant to satiating and weight-reducing effects of high-protein diets

homeostasis/metabolism

increased circulating leptin level ( J:129742 )

abnormal response/metabolism to endogenous compounds ( J:129742 )

• mice are 10 times more sensitive to PYY3-36 compared to wild-type mice

• mice lose 20% of their total body weight after 15 days of treatment with PYY3-36 where as wild-type mice do not experience weight loss but withdrawal of treatment results in mice regaining 60% of the weight they had lost

adipose tissue

increased total body fat amount ( J:129742 )

• total fat content is increased 237+/-40%

abnormal adipose tissue distribution ( J:129742 )

• subcutaneous and internal fat is increased

growth/size/body

obese ( J:129742 )

• mice are 37+/-5% heavier than wild-type mice