Analysis Tools
adipose tissue
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• when fed a high fat diet, mice exhibit a slight increase in fat stores
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behavior/neurological
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• when fed a high fat diet, mice exhibit a slight increase in food intake
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growth/size/body
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• when fed a high fat diet, mice exhibit a slight increase in fat stores
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• mice exhibit a greater increase in weight when fed a high fat diet compared to wild-type mice
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homeostasis/metabolism
hypoglycemia
(
J:129860
)
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• after a 24 hour fast, mice exhibit decreased blood glucose levels (males, 55+/-3 compared to 68+/-5 mg/dl in wild-type mice; females 53+/-2 compared to 67+/-5 mg/dl in wild-type mice)
• acute administration of insulin induces hypoglycemia
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• mice exhibit impaired fasting-mediated increase in pancreatic hormone glucagon
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• following hypoglycemia, mice fail to exhibit an increase in plasma epinephrine levels
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• during fasting and following hypoglycemia, mice fail to exhibit an increase in plasma glucagons compared to wild-type mice
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• glucose plasma levels fail to increase following central administration of 2-deoxyglucose as in wild-type mice
• however, the hyperhagic response initiated by central administration of 2-deoxyglucose is normal
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nervous system
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• neurons do not possess any glutamatergic excitatory postsynaptic current
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