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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fggtm1Lord
targeted mutation 1, Susan T Lord
MGI:3771182
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fggtm1Lord/Fggtm1Lord involves: 129P2/OlaHsd * C57BL/6 MGI:3771183
ht2
 		Fggtm1Lord/Fgg+ involves: 129P2/OlaHsd * C57BL/6 MGI:3771184


Genotype
MGI:3771183
hm1
Allelic
Composition		 Fggtm1Lord/Fggtm1Lord
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fggtm1Lord mutation (0 available); any Fgg mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:129828 )
• 47% of mice die within the first 48 hours of birth from internal bleeding

cardiovascular system
uterine hemorrhage ( J:129828 )
• occurs during pregnancy
hemoperitoneum ( J:129828 )
• all mice suffer from neonatal intra-abdominal hermorrhage

hematopoietic system
decreased hematocrit ( J:129828 )
• 5% reduction in hematocrit
decreased mean corpuscular volume ( J:129828 )
• 9% reduction in corpuscular volume
increased leukocyte cell number ( J:129828 )
• white blood cell count is almost 2-fold higher

homeostasis/metabolism
decreased circulating fibrinogen level ( J:129828 )
• level of serum fibrinogen is one-eighth of normal
abnormal blood coagulation ( J:129828 )
• fibrinogen fails to clot upon addition of thrombin and instead remains soluble
abnormal thrombolysis ( J:129828 )
• calcium fails to protect against plasmin degradation of fibrinogen
abnormal thrombosis ( J:129828 )
• serum fails to clot upon addition of thrombin

immune system
increased leukocyte cell number ( J:129828 )
• white blood cell count is almost 2-fold higher
decreased circulating fibrinogen level ( J:129828 )
• level of serum fibrinogen is one-eighth of normal

reproductive system
uterine hemorrhage ( J:129828 )
• occurs during pregnancy
female infertility ( J:129828 )
• female mice are unable to carry a litter to full-term




Genotype
MGI:3771184
ht2
Allelic
Composition		 Fggtm1Lord/Fgg+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fggtm1Lord mutation (0 available); any Fgg mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating fibrinogen level ( J:129828 )
• level of serum fibrinogen is one-half of normal
abnormal blood coagulation ( J:129828 )
• a small fraction of fibrinogen fails to clot upon addition of thrombin and instead remains soluble
abnormal thrombolysis ( J:129828 )
• calcium is only somewhat protective against plasmin degradation of fibrinogen

immune system
decreased circulating fibrinogen level ( J:129828 )
• level of serum fibrinogen is one-half of normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory