Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(HIV)26Aln transgene insertion 26, Abner Louis Notkins MGI:3771187 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chronic cocaine administration decreases median survival more than in controls
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• 3 of 16 mice die between 2 and 6 months of age with increased proteinuria
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• microcystic tubular dilatation
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• mice are smaller, even prior to the onset of proteinuria
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• young mice develop proteinuria
• heavy proteinuria in young mice is transient and urine protein levels decrease by 60 days of age
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• perivascular lymphocytic infiltrates are seen in the kidneys of mice over 2 months of age
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• mice develop renal disease
• kidneys range from normal to severely affected in 50-day-old mice
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• capillary lumina are narrowed or obliterated in affected kidneys by a marked expansion of mesangial cell matrix
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• microcystic tubular dilatation
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• foot processes of the visceral epithelium are effaced in glomeruli
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• basement membranes are moderately thickened in the kidney epithelium
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• moribund mice exhibit diffuse glomerulosclerosis
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• microcystic tubular dilatation
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• older mice sporadically show arteriopathy in the kidney, heart, skeletal muscle, and thymus
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• capillary lumina are narrowed or obliterated in affected kidneys by a marked expansion of mesangial cell matrix
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• older mice sporadically show myocardial degeneration
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• moribund mice exhibit modestly elevated serum creatinine levels
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• moribund mice exhibit elevated BUN levels
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• death is preceded by subcutaneous edema
• however, no edema is seen during the proteinuria phase
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• young mice develop proteinuria
• heavy proteinuria in young mice is transient and urine protein levels decrease by 60 days of age
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• chronic cocaine administration decreases median survival more than in controls
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• acute cocaine administration results in slightly increased in heart rate, increased left ventricular end diastolic dimensions increased left ventricular mass, increased left ventricular fractional shortening, cardiac interstitial fibrosis and myocardial perivascular fibrosis
• however, cocaine administration reduces the increased QRS duration and QT interval seen in untreated mutants
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• mild iridocyclitis and vitritis in adults with infiltration of mononuclear cells consistent with lymphocytes and monocytes
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• perivascular lymphocytic infiltrates are seen in the kidneys of mice over 2 months of age
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• death is preceded by subcutaneous edema
• however, no edema is seen during the proteinuria phase
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• 30% of mice, predominantly female, show papillomatous skin lesions
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• older mice sporadically show myocardial degeneration
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• older mice sporadically show skeletal muscle degeneration
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• 30% of mice, predominantly female, show papillomatous skin lesions
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• especially in the regions affected by cataractous changes
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• especially in the regions affected by cataractous changes
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• mild iridocyclitis and vitritis in adults with infiltration of mononuclear cells consistent with lymphocytes and monocytes
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• lens epithelial cell development abnormalities are detected as early as E14.5, with malformation of an embryonal lens nucleus and poor closure of the lens suture lines
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• lenses show extensive vacuolation
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• cataracts are present by E14.5 and are present in 100% of mice
• cataracts are characterized by the malformation or impaired formation of fetal lens nucleus and poor closure of lens suture lines, indicating congenital nuclear cataracts
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• lenses that are spherophakic exhibit cortical cataractous changes of vacuoles and globulin formation, liquefaction, and fragmentation
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• especially in the regions affected by cataractous changes
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• especially in the regions affected by cataractous changes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| acquired immunodeficiency syndrome | DOID:635 | J:84552 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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