Phenotypes associated with this allele

• Allele Symbol: Hpgd^tm1Ljm
• Allele Name: targeted mutation 1, Louis J Muglia
• Allele ID: MGI:3771208
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpgd^tm1Ljm/Hpgd^tm1Ljm	involves: 129S6/SvEvTac * C57BL/6	MGI:3771211
ht2	Hpgd^tm1Ljm/Hpgd^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3771212

Genotype
MGI:3771211

hm1

• Allelic Composition: Hpgd^tm1Ljm/Hpgd^tm1Ljm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal corpus luteum morphology ( J:130001 )

♀ • unlike in wild-type mice, there is no evidence of lutenolysis at E18.5 in the pregnant dam

early parturition ( J:130001 )

♀ • labor occurs almost a full day earlier than in wild-type mice

homeostasis/metabolism

increased circulating progesterone level ( J:130001 )

• unlike in wild-type mice, pregnant females fail to exhibit a drop in progesterone levels as labor approaches

increased prostaglandin level ( J:130001 )

• at E17.5 and E18.25, pregnant dams exhibit elevated PGE2 levels in the placenta and ovaries

• at E17.5, uterus and ovaries PGF2alpha concentrations are elevated compared to in wild-type mice

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:130001 )

♀ • unlike in wild-type mice, there is no evidence of lutenolysis at E18.5 in the pregnant dam

Genotype
MGI:3771212

ht2

• Allelic Composition: Hpgd^tm1Ljm/Hpgd⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

reproductive system

early parturition ( J:130001 )

♀ • labor occurs half a day earlier than in wild-type mice or when the sire is wild-type