Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Iapp)6Soel
• Allele Name: transgene insertion 6, Walter C Soeller
• Allele ID: MGI:3771295
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-Iapp)6Soel/Tg(Ins2-Iapp)6Soel	involves: FVB/N	MGI:3771296

Genotype
MGI:3771296

tg1

• Allelic Composition: Tg(Ins2-Iapp)6Soel/Tg(Ins2-Iapp)6Soel
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:130022 )

• islet cells exhibit an increased expression of the endoplasmic reticulum (ER) chaperone Hspa5

• however, there is no increase in the expression of ER stress markers and no change in the number of beta cells

immune system

decreased susceptibility to autoimmune diabetes ( J:130022 )

• unlike Tg(IAPP)6Jdm homozygotes, mice do not develop diabetes at 10 weeks of age