normal phenotype
• mice did not exhibit any obvious phenotype
|
Allele Symbol Allele Name Allele ID |
Rps6kb2tm1Gtho targeted mutation 1, George Thomas MGI:3771299 |
||||||||||||||||||||||||||||||||
Summary |
7 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice did not exhibit any obvious phenotype
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lethality is comparable to that observed on a mixed background
|
• lethality is comparable to that observed on a mixed background
|
• lethality is comparable to that observed on a mixed background
|
• growth retardation is comparable to that observed on a mixed background
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age
|
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• muscle cells are resistant to the growth inhibition triggered by rapamycin or nutrient deprivation
• however, sensitivity to rapamycin and nutrient deprivation could be restored by transfection of a constitutively active AMPK
|
• in the gastrocnemius
|
• muscle cell diameter is reduced by 20% compared to wild-type (6.2+/-0.2 um compared to 8.9+/-0.5 um for wild-type cells in culture)
|
• ATP levels in muscle cells is reduced 34% and AMP levels are increased 40% compared to in wild-type mice
• mitochondrial enzyme activity of citrate synthase and cytochrome c oxidase in myotubes is increased 50% to 70% compared to wild-type
|
• mitochondrial fatty acid beta-oxidation was also augmented in mutant muscle cell cultures, as measured by [3H]-palmitate oxidation
|
• in the gastrocnemius
|
• in the gastrocnemius, the total lipid content is reduced by half compared to in wild-type mice
|
• mitochondrial mass in myotubes and white adipose tissue is increased compared to in wild-type mice
|
• ATP-dependent and -independent oxidative capacity is increased in skeletal muscle
|
• mitochondrial fatty acid beta-oxidation was also augmented in mutant muscle cell cultures, as measured by [3H]-palmitate oxidation
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only 65% of expected embryos survive until weaning
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• half of the mice that are born alive die within hours with signs of cyanosis
• however, mice that survive day 1 usually reach adulthood
|
• one third of mice are born dead without having emerged from their yolk sacs or detached from their placenta
|
• only 30% of expected embryos survive until weaning
|
• nonviable and cyanotic mice exhibit dilated heart chambers
|
• nonviable and cyanotic mice exhibit hyperemia of internal organs
|
• nonviable mice exhibit several sites of hemorrhaging and red blood cells are detected throughout the myocardium
red blood cells are detected throughout the myocardium
|
• mice delivered by Caesarian section develop transient signs of hypoxia (bluish skin)
|
• mice exhibit the same growth rate as Rps6kb1tm1Gtho homozygotes
|
• mice produce small litters that exhibit a high incidence of perinatal lethality
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• pancreatic beta cells are 4-fold larger than wild-type cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/21/2024 MGI 6.24 |
![]() |
|