Phenotypes associated with this allele

• Allele Symbol: Siglecg^tm1Yliu
• Allele Name: targeted mutation 1, Yang Liu
• Allele ID: MGI:3771358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglecg^tm1Yliu/Siglecg^tm1Yliu	C57BL/6-Siglecg^tm1Yliu	MGI:3771359

Genotype
MGI:3771359

hm1

• Allelic Composition: Siglecg^tm1Yliu/Siglecg^tm1Yliu
• Genetic Background: C57BL/6-Siglecg^tm1Yliu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B-1a cell number ( J:130017 )

• 5-fold increase in the number of these cells isolated from the peritoneal cavity

• 2-fold increase in numbers of these cells in spleens of 2 week old mice

• no difference in number B-1a cells in adult spleen

increased pre-B cell number ( J:130017 )

• 4-fold expansion in the number of B-1a cell progenitors (CD19-positive, B220-low) in the bone marrow of adults

• bone marrow from mutant mice is twice as efficient in reconstituting the entire B cell compartment of irradiated recipient mice

increased IgM level ( J:130017 )

• serum levels of IgM are 5-10 fold higher than normal

hematopoietic system

increased B-1a cell number ( J:130017 )

• 5-fold increase in the number of these cells isolated from the peritoneal cavity

• 2-fold increase in numbers of these cells in spleens of 2 week old mice

• no difference in number B-1a cells in adult spleen

increased pre-B cell number ( J:130017 )

• 4-fold expansion in the number of B-1a cell progenitors (CD19-positive, B220-low) in the bone marrow of adults

• bone marrow from mutant mice is twice as efficient in reconstituting the entire B cell compartment of irradiated recipient mice

increased IgM level ( J:130017 )

• serum levels of IgM are 5-10 fold higher than normal