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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		CbllTg(Alb-KL)7-2Mhos
transgene insertion 7-2, Mikio Hoshino
MGI:3771564
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		CbllTg(Alb-KL)7-2Mhos/CbllTg(Alb-KL)7-2Mhos involves: C57BL/6 MGI:3771565
cx2
 		Ptf1atm1.1(cre)Cvw/CbllTg(Alb-KL)7-2Mhos involves: C57BL/6 MGI:3771566


Genotype
MGI:3771565
hm1
Allelic
Composition		 CbllTg(Alb-KL)7-2Mhos/CbllTg(Alb-KL)7-2Mhos
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:100997 )
• lifespan of mice is at least 2 years of age compared to mice homozygous for a null allele of Ptf1a that die shortly after birth

nervous system
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop
thin external granule cell layer ( J:100997 )
• the EGL is much thinner at 4 days after birth compared to age-matched controls
• the EGL continues to thin with development from apoptosis until it disappears by 2 weeks after birth
abnormal inferior olivary complex morphology ( J:100997 )
• the inferior olivary nucleus and the pontine nuclei are absent in adults
• both structures are present at birth but regress 4 days later and disappear by 6 days after birth due to apoptosis
absent cerebellar lobules ( J:100997 )
• a small cerebellum without lobules is present in mice at postnatal day 4
absent cerebellum ( J:100997 )
• adults lack all cerebellar cortical layers
abnormal GABAergic neuron morphology ( J:100997 )
• GABA neurons fail to develop in the cerebellar ventricular zone
abnormal glutaminergic neuron morphology ( J:100997 )
• within the cerebellum rudiment, there are 2.3 fold less glutaminergic neurons compared to similar area in wild-type brain

behavior/neurological
tremors ( J:100997 )
• is observed in adults
ataxia ( J:100997 )
• occurs in adults
impaired coordination ( J:100997 )
• uncoordinated locomotion is observed in adults

growth/size/body
decreased body size ( J:100997 )
• body sizes are generally smaller than littermate controls

cellular
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop




Genotype
MGI:3771566
cx2
Allelic
Composition		 Ptf1atm1.1(cre)Cvw/CbllTg(Alb-KL)7-2Mhos
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CbllTg(Alb-KL)7-2Mhos mutation (0 available); any Cbll mutation (0 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop similar to CbllTg(Alb-KL)7-2Mhos homozygotes
abnormal GABAergic neuron morphology ( J:100997 )
• failure of GABA neurons to develop by 4 days after birth is similar to CbllTg(Alb-KL)7-2Mhos homozygotes

cellular
abnormal Purkinje cell differentiation ( J:100997 )
• purkinje cells fail to develop similar to CbllTg(Alb-KL)7-2Mhos homozygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory