Phenotypes associated with this allele

• Allele Symbol: Pyy^tm1Mws
• Allele Name: targeted mutation 1, Mark W Sleeman
• Allele ID: MGI:3771716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pyy^tm1Mws/Pyy^tm1Mws	involves: C57BL/6J	MGI:3771731

Genotype
MGI:3771731

hm1

• Allelic Composition: Pyy^tm1Mws/Pyy^tm1Mws
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal lumbar vertebrae morphology ( J:130105 )

• lumbar vertebral bodies exhibit a 35% reduction in trabecular bone volume and a 28% reduction in trabecular number compared to in wild-type mice

• in a compression test on the L5 vertebrae of a 9 month old mouse, the maximal load is decreased 33% (13.62+/-1.56 N compared to 20.45+/-2.77 N in wild-type mice)

• mice are more sensitive to loss of bone mass, especially in the lumbar vertebra, due to estrogen-depletion that is not accompanied by weight loss than wild-type mice

decreased bone mineral content ( J:130105 )

• bone mineral density and bone mineral content are decreased by 5% to 10% compared to in wild-type mice

decreased bone mineral density ( J:130105 )

• bone mineral density and bone mineral content are decreased by 5% to 10% compared to in wild-type mice

• however, there is no change in serum measurements of dietary components that might affect bone mineralization

• mice maintain a reduced bone mineral density when fed a high-fat diet despite weight gain

decreased bone mass ( J:130105 )

• mice are more sensitive to loss of bone mass, especially in the lumbar vertebra, due to estrogen-depletion that is not accompanied by weight loss than wild-type mice

growth/size/body

growth/size/body region phenotype ( J:130105 )

N • mice exhibit normal body weight when fed a standard diet

decreased lean body mass ( J:130105 )

• when fed a high fat diet, female, but not male, mice exhibit an increase in body fat mass with a decrease in lean mass

increased susceptibility to weight gain ( J:130105 )

• when fed a high-fat diet, mice exhibit a small increase in body weight compared to wild-type mice (11% increase in males and 21% increased in females)

adipose tissue

increased percent body fat/body weight ( J:130105 )

• when fed a high fat diet, female, but not male, mice exhibit an increase in body fat mass with a decrease in lean mass

behavior/neurological

behavior/neurological phenotype ( J:130105 )

N • mice exhibit normal food intake when fed a standard diet