Phenotypes associated with this allele

• Allele Symbol: Pnrc2^tm1Shch
• Allele Name: targeted mutation 1, Shiuan Chen
• Allele ID: MGI:3771820
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnrc2^tm1Shch/Pnrc2^tm1Shch	involves: 129S1/Sv * C57BL/6	MGI:3771821

Genotype
MGI:3771821

hm1

• Allelic Composition: Pnrc2^tm1Shch/Pnrc2^tm1Shch
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pnrc2^tm1Shch/Pnrc2^tm1Shch mice have a lean phenotype

adipose tissue

abnormal fat cell morphology ( J:130294 )

• adipocyte diameter is reduced in inguinal white adipose tissue compared to in wild-type mice

• when fed a high fat diet, adipocytes are smaller than in wild-type mice

abnormal fat pad morphology ( J:130294 )

• when fed a high fat diet, mice exhibit less gonadal, inguinal and brown fat pad weight (21%, 67%, and 32% less respectively) compared to wild-type mice

decreased gonadal fat pad weight ( J:130294 )

• the gonadal fat pad is reduced in males (0.71+/-0.09 g compared to 1.11+/-0.58 g in wild-type mice) and females (0.68+/-0.28 g compared to 1.27+/-0.94 g in wild-type mice)

decreased inguinal fat pad weight ( J:130294 )

• the inguinal fat pad is reduced 57% in males (0.40+/-0.14 g compared to 0.94+/-0.3 g in wild-type) and 47% in females (0.38+/-0.13 g compared to 0.72+/-0.33 g in wild-type)

decreased percent body fat/body weight ( J:130294 )

• 26.2+/-8.89% compared to 38.4+/-8.24% at 12 months of age

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:130294 )

• mice exhibit a resistance to a drop in body temperature upon fasting unlike wild-type mice

decreased circulating leptin level ( J:130294 )

• leptin levels are decreased 60% (1.5+/-0.59 ng/ml compared to 4.01+/-0.24 ng/ml in wild-type mice)

increased energy expenditure ( J:130294 )

decreased susceptibility to diet-induced obesity ( J:130294 )

• when fed a high fat diet, male mice exhibit less weight gain (34.64+/-2.21% compared to 104.33+/-11.56% in wild-type male mice)

increased oxygen consumption ( J:130294 )

growth/size/body

decreased body weight ( J:130294 )

• by 12 months of age male mice weigh 20% less than wild-type (37.75+/-5.68 g compared to 46.75+/-7.09 g) when fed a standard diet

decreased susceptibility to diet-induced obesity ( J:130294 )

• when fed a high fat diet, male mice exhibit less weight gain (34.64+/-2.21% compared to 104.33+/-11.56% in wild-type male mice)

increased susceptibility to weight loss ( J:130294 )

• mice increased weight loss when fasting (11.36+/-5.64% compared to 4.38+/-1.15% in wild-type mice)

behavior/neurological

abnormal eating behavior ( J:130294 )

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:130294 )

• when fed a high fat diet