Phenotypes associated with this allele

• Allele Symbol: Plagl2^tm1Wjmv
• Allele Name: targeted mutation 1, Wim J M Van de Ven
• Allele ID: MGI:3771822
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plagl2^tm1Wjmv/Plagl2^tm1Wjmv	involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	MGI:3771827

Genotype
MGI:3771827

hm1

• Allelic Composition: Plagl2^tm1Wjmv/Plagl2^tm1Wjmv
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:130260 )

• only 15% of mice survive the first week after birth and less than 5% of mice reach weaning

homeostasis/metabolism

abnormal intestinal lipid absorption ( J:130260 )

• intestines contain 25.3+/-1.5 mg triglycerides per gram compared to 15.0+/-1.27 mg/g in wild-type mice

• modified lipids exit from the enterocytes but fail to enter the interstitial lacteal vessels

increased circulating cholesterol level ( J:130260 )

• 119.9+/-36.4 mg/dl compared to 54.9+/-1.0 mg/dl in wild-type mice

increased circulating triglyceride level ( J:130260 )

• 101.6+/-31.3 mg/dl compared to 46.3+/-4.5 mg/dl in wild-type mice

digestive/alimentary system

abnormal intestine morphology ( J:130260 )

• the lamina propria and submucosa of the small bowel are distended and prominent vacuoles in the jejunal enterocytes are present unlike in wild-type mice

• the gut interstitium is filled with mature chylomicrons unbound by endothelium unlike in wild-type mice

• intestinal capillaries and pother lamina propria elements are compressed by excess liquid unlike in wild-type mice

abnormal intestinal lipid absorption ( J:130260 )

• intestines contain 25.3+/-1.5 mg triglycerides per gram compared to 15.0+/-1.27 mg/g in wild-type mice

• modified lipids exit from the enterocytes but fail to enter the interstitial lacteal vessels

growth/size/body

decreased body weight ( J:130260 )

• shortly after birth

slow postnatal weight gain ( J:130260 )

• mice fail to gain weight after birth