Phenotypes associated with this allele

• Allele Symbol: Phb1^{Gt(XT0035)Wtsi}
• Allele Name: gene trap XT0035, Wellcome Trust Sanger Institute
• Allele ID: MGI:3771851
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phb1^Gt(XT0035)Wtsi/Phb1^Gt(XT0035)Wtsi	involves: 129P2/OlaHsd * C57BL	MGI:3771854
ht2	Phb1^Gt(XT0035)Wtsi/Phb1^+	involves: 129P2/OlaHsd * C57BL	MGI:3771855

Genotype
MGI:3771854

hm1

• Allelic Composition: Phb1^{Gt(XT0035)Wtsi}/Phb1^{Gt(XT0035)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:130064 )

• although embryos are present at E3.5 they die before E6.5

Genotype
MGI:3771855

ht2

• Allelic Composition: Phb1^{Gt(XT0035)Wtsi}/Phb1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:130064 )

♀ • upon hormone treatment to induce mammary gland ductal side branching and alveologenesis, mice produce more alveolar lateral budding and ductal side-branching, and a 1.96-fold increase in alveolar bud number per field compared to in wild-type mice

integument

abnormal branching of the mammary ductal tree ( J:130064 )

♀ • upon hormone treatment to induce mammary gland ductal side branching and alveologenesis, mice produce more alveolar lateral budding and ductal side-branching, and a 1.96-fold increase in alveolar bud number per field compared to in wild-type mice