Phenotypes associated with this allele

• Allele Symbol: Dmbt1^tm1Janm
• Allele Name: targeted mutation 1, Jan Mollenhauer
• Allele ID: MGI:3771872
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmbt1^tm1Janm/Dmbt1^tm1Janm	involves: 129P2/OlaHsd * C57BL/6	MGI:3771950

Genotype
MGI:3771950

hm1

• Allelic Composition: Dmbt1^tm1Janm/Dmbt1^tm1Janm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:130258 )

• mice treated with 2.5% dextran sulfate sodium exhibit 4% more weight loss, 10-20% increase in histological disease scores, and increased transcription of Il6, Tnf, and Nod2 genes by colon tissue

immune system

increased susceptibility to induced colitis ( J:130258 )

• mice treated with 2.5% dextran sulfate sodium exhibit 4% more weight loss, 10-20% increase in histological disease scores, and increased transcription of Il6, Tnf, and Nod2 genes by colon tissue