Phenotypes associated with this allele

• Allele Symbol: Bcam^tm1Ics
• Allele Name: targeted mutation 1, Mouse Clinical Institute
• Allele ID: MGI:3771876
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcam^tm1Ics/Bcam^tm1Ics	involves: 129P2/OlaHsd * C57BL/6	MGI:3771951

Genotype
MGI:3771951

hm1

• Allelic Composition: Bcam^tm1Ics/Bcam^tm1Ics
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:130191 )

N • kidney function and relative size are normal

abnormal renal glomerulus morphology ( J:130191 )

• 40% to 50% of glomeruli are abnormal in males and 80% to 90% of glomeruli are abnormal in females

• glomeruli exhibit thickening of the lamina densa with numerous protrusions towards the podocytic side

abnormal glomerular capillary morphology ( J:130191 )

• the number of visible capillary lumens is less than in wild-type mice

digestive/alimentary system

abnormal colon morphology ( J:130191 )

• smooth muscle of the colon is thickened and disorganized with abnormally enlarged spaces between muscle cells

• however, intestinal transit is normal

abnormal jejunum morphology ( J:130191 )

• smooth muscle of the jejunum is thickened and disorganized with abnormally enlarged spaces between muscle cells

• however, intestinal transit is normal

growth/size/body

increased body mass index ( J:130191 )

• body mass index for males is 0.34 compared to 0.28 for wild-type mice

increased body weight ( J:130191 )

• males weigh 36+/-2.6 g compared to 29+/-5.9 g for wild-type mice and females weigh 25.7 g compared to 23.3+/-1.5 g for wild-type mice

cardiovascular system

abnormal glomerular capillary morphology ( J:130191 )

• the number of visible capillary lumens is less than in wild-type mice