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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rgs13tm1Drue
targeted mutation 1, Kirk M Druey
MGI:3771964
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rgs13tm1Drue/Rgs13tm1Drue B6.129S-Rgs13tm1Drue MGI:3771965


Genotype
MGI:3771965
hm1
Allelic
Composition		 Rgs13tm1Drue/Rgs13tm1Drue
Genetic
Background		 B6.129S-Rgs13tm1Drue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs13tm1Drue mutation (1 available); any Rgs13 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:130209 )
• bone marrow-derived mast cells (BMMCs) exhibit increased degranulation over a greater range of antigen concentration than wild-type cells
increased susceptibility to type I hypersensitivity reaction ( J:130209 )
• passive cutaneous anaphylaxis is increased 2-fold compared to in wild-type mice
• passive systemic anaphylaxis is increased compared to in wild-type mice

hematopoietic system
abnormal mast cell physiology ( J:130209 )
• bone marrow-derived mast cells (BMMCs) exhibit increased degranulation over a greater range of antigen concentration than wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory