About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim24tm1Los
targeted mutation 1, Regine Losson
MGI:3772050
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Raratm3Ipc/Raratm3Ipc
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los 		involves: 129/Sv * C57BL/6 * DBA * SJL MGI:3772096
cn2
 		Raratm3Ipc/Rara+
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los 		involves: 129/Sv * C57BL/6 * DBA * SJL MGI:3772097


Genotype
MGI:3772096
cn1
Allelic
Composition		 Raratm3Ipc/Raratm3Ipc
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm3Ipc mutation (0 available); any Rara mutation (79 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Trim24tm1Los mutation (0 available); any Trim24 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:130210 )
• slight but significant increase in the percentage of Ki67-positive hepatocytes from 14 week old mice compared to age-matched control mice

cellular
increased hepatocyte proliferation ( J:130210 )
• slight but significant increase in the percentage of Ki67-positive hepatocytes from 14 week old mice compared to age-matched control mice




Genotype
MGI:3772097
cn2
Allelic
Composition		 Raratm3Ipc/Rara+
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm3Ipc mutation (0 available); any Rara mutation (79 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Trim24tm1Los mutation (0 available); any Trim24 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:130210 )
• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver

cellular
increased hepatocyte proliferation ( J:130210 )
• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory