Phenotypes associated with this allele

• Allele Symbol: Trim24^tm1.1Los
• Allele Name: targeted mutation 1.1, Regine Losson
• Allele ID: MGI:3772051
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim24^tm1.1Los/Trim24^tm1.1Los	involves: 129/Sv * C57BL/6 * SJL	MGI:3772094
cx2	Rara^tm3.1Ipc/Rara^+ Trim24^tm1.1Los/Trim24^tm1.1Los	involves: 129/Sv * C57BL/6 * SJL	MGI:3772095

Genotype
MGI:3772094

hm1

• Allelic Composition: Trim24^tm1.1Los/Trim24^tm1.1Los
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte proliferation ( J:130210 )

• almost 5-fold more hepatocytes are in the S phase in 14 week old mice compared to wild-type controls as measured by BrdU incorporation

• there is a 2- to 3-fold increase in the number of Ki67-positive hepatocytes starting at 3 weeks of age and persisting into adulthood

• the percentage of proliferating hepatocytes drops more than 2-fold upon administration of an antagonist to retinoic acid receptors

increased liver tumor incidence ( J:130210 )

• 80% of male mice and 69% of female mice have hepatic tumors between the ages of 9 and 29 months

increased hepatocellular carcinoma incidence ( J:130210 )

• malignant tumors first become evident in the liver in 20% of mice at one year of age

• malignant tumors are found in 41% of mice between 13-19 months of age and in 80% of mice in 19-29 months of age

• tumors generally consist of two types: trabecular with well-differentiated cells and solid, with poorly differentiated cells

• metastasis to lung is observed in 13% of mice

increased liver adenoma incidence ( J:130210 )

• 53% of nine month old mice exhibit adenomas compressing the nontumoral parenchyma

neoplasm

increased liver tumor incidence ( J:130210 )

• 80% of male mice and 69% of female mice have hepatic tumors between the ages of 9 and 29 months

increased hepatocellular carcinoma incidence ( J:130210 )

• malignant tumors first become evident in the liver in 20% of mice at one year of age

• malignant tumors are found in 41% of mice between 13-19 months of age and in 80% of mice in 19-29 months of age

• tumors generally consist of two types: trabecular with well-differentiated cells and solid, with poorly differentiated cells

• metastasis to lung is observed in 13% of mice

increased liver adenoma incidence ( J:130210 )

• 53% of nine month old mice exhibit adenomas compressing the nontumoral parenchyma

cellular

polyploidy ( J:130210 )

• 15 % of hepatocyte nuclei from 14 week old mice have 8N DNA content and 4% have 16N DNA compared to less the 5% of wild-type hepactocytes having a nuclei DNA content greater than 4N

increased hepatocyte proliferation ( J:130210 )

• almost 5-fold more hepatocytes are in the S phase in 14 week old mice compared to wild-type controls as measured by BrdU incorporation

• there is a 2- to 3-fold increase in the number of Ki67-positive hepatocytes starting at 3 weeks of age and persisting into adulthood

• the percentage of proliferating hepatocytes drops more than 2-fold upon administration of an antagonist to retinoic acid receptors

Genotype
MGI:3772095

cx2

• Allelic Composition: Rara^tm3.1Ipc/Rara⁺; Trim24^tm1.1Los/Trim24^tm1.1Los
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

liver/biliary system

increased hepatocyte proliferation ( J:130210 )

• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice

• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara

neoplasm

neoplasm ( J:130210 )

N • no liver tumors are found in mice between 12 and 15 months of age compared to 70% liver tumor incidence in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara

cellular

increased hepatocyte proliferation ( J:130210 )

• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice

• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara