All Phenotypes Lhx2<tm1Monu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lhx2^tm1Monu
targeted mutation 1, Edwin S Monuki
MGI:3772179

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Lhx2^tm1Monu/Lhx2^tm1Monu	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:3772184
cn2	Emx1^tm1(cre)Yql/Emx1⁺ Lhx2^tm1Monu/Lhx2^tm1Monu	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3772185
cn3	Lhx2^tm1Monu/Lhx2^tm1Monu Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA	MGI:4453348
cn4	Lhx2^tm1Monu/Lhx2^tm1Dra Tg(CAG-cre/Esr1*)5Amc/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA	MGI:4453346
cn5	Lhx2^tm1Monu/Lhx2^tm1Monu Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: 129P2/OlaHsd * CD-1 * FVB/N	MGI:3772183

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Lhx2^tm1Monu/Lhx2^tm1Monu
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:130167 )

• at E12.5, following tamoxifen treatment at E8.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon

abnormal cerebral cortex morphology ( J:130167 )

• at E12.5, following tamoxifen treatment at E8.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon

• treatment with tamoxifen at E10.5 results in subtle to inapparent abnormalities in the cortical hem at E12.5

Allelic Composition	Emx1^tm1(cre)Yql/Emx1⁺ Lhx2^tm1Monu/Lhx2^tm1Monu
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:130167 )

• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5

Allelic Composition	Lhx2^tm1Monu/Lhx2^tm1Monu Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:159209 )

• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair

abnormal hair cycle anagen phase ( J:159209 )

• unable to develop beyond Sub-stage III and assemble a normal hair shaft

Allelic Composition	Lhx2^tm1Monu/Lhx2^tm1Dra Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2^tm1Dra mutation (0 available); any Lhx2 mutation (12 available)
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:159209 )

• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair

abnormal hair cycle anagen phase ( J:159209 )

• unable to develop beyond Sub-stage III and assemble a normal hair shaft

Allelic Composition	Lhx2^tm1Monu/Lhx2^tm1Monu Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: 129P2/OlaHsd * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:130167 )

• at E12.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon

abnormal cerebral cortex morphology ( J:130167 )

• at E12.5, mice display an expansion of the cortical hem and a reduction in dorsal telencephalon

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