All Phenotypes Rnf2<tm1Mvi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rnf2^tm1Mvi
targeted mutation 1, Miguel Vidal
MGI:3772186

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn/0	involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL	MGI:3772194
cn2	Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Nes-cre/ERT2)5-1Imayo/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4413349
cn3	Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * CBA	MGI:3772192
cn4	Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Rnf2^tm1Mvi/Rnf2^tm1Mvi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL	MGI:3772193
cn5	Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Rnf2^tm1Mvi/Rnf2^tm1Mvi	involves: 129S/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4413348

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Rnf2^tm1Mvi mutation (1 available); any Rnf2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:130397 )

• mice die at 11 weeks after treatment with pIpC with splenomegalia and hepatomegalia

hematopoietic system

hematopoietic system phenotype ( J:130397 )

N	• the deficits in splenocytes, bone marrow cells and pre-B cells observed in Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn mice treated with pIpC at 6 to 12 weeks is not observed

enlarged spleen ( J:130397 )

abnormal common myeloid progenitor cell morphology ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, mice exhibit an increase in myeloid colony forming units relative to wild-type mice

neoplasm

increased lymphoma incidence ( J:130397 )

• following treatment with pIpC, mice develop lymphomas at an earlier age of onset compared to in Cdkn2a^tm1Rdp homozygotes

liver/biliary system

enlarged liver ( J:130397 )

immune system

enlarged spleen ( J:130397 )

growth/size/body

enlarged liver ( J:130397 )

enlarged spleen ( J:130397 )

Allelic Composition	Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf2^tm1Mvi mutation (1 available); any Rnf2 mutation (36 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:154927 )

• following exposure to tamoxifen at E13.5, the late-born/upper-layer neurons in the cortical plate at P6.5 that had been labeled with BrdU at E19.0 is greater than in control Rnf2^tm1Mvi homozygotes

cellular

abnormal neuron differentiation ( J:154927 )

Allelic Composition	Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf2^tm1Mvi mutation (1 available); any Rnf2 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:130397 )

• when cells from a mouse treated with pIpC at 6 to 12 weeks where exposed to IL-7 in a clonogenic assay, the number and size of pre-B cell colonies is reduced compared to in wild-type mice

abnormal bone marrow cell morphology/development ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, the progenitor compartment is enlarged and the number of hematopoietic stem cells is increased compared to in wild-type mice

abnormal common myeloid progenitor cell morphology ( J:130397 )

• when cells from a mouse treated with pIpC at 6 to 12 weeks where exposed to IL-7 in a clonogenic assay, the number of myeloid colony forming units is increased 2-fold, all types of myeloid-derives cells are present at a 6-fold higher level, and granulo-mono-erythromegakaryocitic colonies are denser and contain a 5-fold increase in primitive common myeloid progenitors relative to in wild-type mice

decreased bone marrow cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, the total number of bone marrow cells is nearly one third less than in wild-type mice

decreased erythrocyte cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, mice exhibit decreased erythrocyte numbers compared to in wild-type mice

thrombocytosis ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, some mice are thrombocytotic

decreased B cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, the number of lymphoid B cells is slightly decreased compared to in wild-type mice

decreased monocyte cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, mice exhibit decreased splenocyte numbers compared to in wild-type mice

immune system

abnormal B cell differentiation ( J:130397 )

• when cells from a mouse treated with pIpC at 6 to 12 weeks where exposed to IL-7 in a clonogenic assay, the number and size of pre-B cell colonies is reduced compared to in wild-type mice

decreased B cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, the number of lymphoid B cells is slightly decreased compared to in wild-type mice

decreased monocyte cell number ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, mice exhibit decreased splenocyte numbers compared to in wild-type mice

Allelic Composition	Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Rnf2^tm1Mvi/Rnf2^tm1Mvi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)
Rnf2^tm1Mvi mutation (1 available); any Rnf2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:130397 )

• when cells are exposed to tamoxifen ex vivo, the progenitor compartment is increased compared to unexposed cells

abnormal common myeloid progenitor cell morphology ( J:130397 )

• however, myeloid cell apoptosis rates and differentiation are normal

• when cells are exposed to tamoxifen ex vivo, the number of myeloid colony forming units is increased compared to unexposed cells

• when cells are exposed to tamoxifen ex vivo, the proliferation of myeloid precursor cells is increased compared to unexposed cells

decreased B cell number ( J:130397 )

• when cells are exposed to tamoxifen ex vivo, fewer pre-B cells are present compared to unexposed cells

immune system

decreased B cell number ( J:130397 )

• when cells are exposed to tamoxifen ex vivo, fewer pre-B cells are present compared to unexposed cells

Allelic Composition	Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Rnf2^tm1Mvi/Rnf2^tm1Mvi
Genetic Background	involves: 129S/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Rnf2^tm1Mvi mutation (1 available); any Rnf2 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:154927 )

• E11.5 neural precursor cells cultured for 9 days in the presence of S33Y beta-catenin and tamoxifen exhibit enhanced neuronal differentiation compared with similarly treated control Rnf2^tm1Mvi cells

• E17.5 neural precursor cells cultured for 3 days in the presence of S33Y beta-catenin and tamoxifen exhibit enhanced neuronal differentiation compared with similarly treated control Rnf2^tm1Mvi cells

• neuronal precursor cells treated with tamoxifen and subjected to growth factor deprivation at the late stage (12 days in culture) exhibit reduced astrocyte differentiation compared with similarly treated control Rnf2^tm1Mvi cells

• at P2.5, tamoxifen-treated mice exhibit reduced astrocytic differentiation compared with similarly treated control Rnf2^tm1Mvi cells

cellular

abnormal neuron differentiation ( J:154927 )

• at P2.5, tamoxifen-treated mice exhibit reduced astrocytic differentiation compared with similarly treated control Rnf2^tm1Mvi cells

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