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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou5f1tm2Jae
targeted mutation 2, Rudolf Jaenisch
MGI:3772191
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pou5f1tm2Jae/Pou5f1tm2Jae involves: 129S4/SvJae * C57BL/6 MGI:3772221
cn2
 		Hdac2tm1.1Eem/Hdac2tm1.1Eem
Pou5f1tm2Jae/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:4950699
cx3
 		Mir34atm1.1Lhe/Mir34atm1.1Lhe
Pou5f1tm2Jae/Pou5f1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5308797


Genotype
MGI:3772221
hm1
Allelic
Composition		 Pou5f1tm2Jae/Pou5f1tm2Jae
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou5f1tm2Jae mutation (1 available); any Pou5f1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130248 )
• mice are viable and fertile; some murine embryonic fibroblasts treated with specific transcription factors (Pou5f1, Sox2, c-myc, and Klf4) have the properties of induced pluripotent stem (iPS) cells. Such iPS cells have the DNA methylation, gene expression and chromatin state of embryonic stem cells and can form viable chimeras, contribute to the germ line, and generate live late-term embryos when injected into tetraploid blastocysts.




Genotype
MGI:4950699
cn2
Allelic
Composition		 Hdac2tm1.1Eem/Hdac2tm1.1Eem
Pou5f1tm2Jae/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2tm1.1Eem mutation (0 available); any Hdac2 mutation (40 available)
Pou5f1tm2Jae mutation (1 available); any Pou5f1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:171358 )
• mouse embryonic fibroblasts transduced with a cre-expressing adenovirus and a Mir302/367-expressing virus form Pou5f1-GFP+ produce viable induced pluripotent stem cells (iPSCs) unlike wild-type cells in the absence of valproic acid




Genotype
MGI:5308797
cx3
Allelic
Composition		 Mir34atm1.1Lhe/Mir34atm1.1Lhe
Pou5f1tm2Jae/Pou5f1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34atm1.1Lhe mutation (1 available); any Mir34a mutation (9 available)
Pou5f1tm2Jae mutation (1 available); any Pou5f1 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:180692 )
• induced mouse embryonic fibroblasts exhibit a greater than 4-fold increase in reprogramming efficiency and generation of induced pluripotent stem cell compared with wild-type and Mir34atm1.1Ghan cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory