Analysis Tools
mortality/aging
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• male mice rarely survive past 4 to 6 weeks of age
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homeostasis/metabolism
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• significantly increased levels observed in male mutant mice
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• significantly increased levels observed in male mutant mice
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• significantly increased levels observed in male mutant mice
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• significantly increased levels observed in male mutant mice
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liver/biliary system
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• a highly compressed parenchyma results from the presence of a large bladder
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renal/urinary system
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• large bladders leads to distended kidneys and pelvis
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• ureters are severely distended due to fluid from enlarged bladders
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• mice exhibit a severe distention of the bladder with a thin wall and lacking any significant smooth muscle layer
• male mice show show obvious signs of distension at birth and exhibit a rapid pathologic progression
• female mice have a slower pathological progression and only develop overt distended bladders latter in life
• luminal opening of bladder to urethra is small
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• a distended bladder is observable in male mice at E18 lacks a smooth muscle layer
• female mice have a less severe morphology of the bladder at E18 with a moderate distension and a thin muscle layer
• a highly disorganized muscle layer is evident around the bladder at E15 with only patchy areas of differentiating muscle cells evident
• there is a 5- to 10-fold increase in the number of apoptotic cells in the mesenchymal layer at E15 compared to wild-type controls
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• male bladders are completely refilled within 1 to 2 hours after percutaneous drainage
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| kidney disease | DOID:557 | J:207566 | ||
