All Phenotypes Tor1a<tm2Yql> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tor1a^tm2Yql
targeted mutation 2, Yuqing Li
MGI:3772564

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Yql/Emx1⁺ Tor1a^tm2Yql/Tor1a^tm2Yql	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3772569

Allelic Composition	Emx1^tm1(cre)Yql/Emx1⁺ Tor1a^tm2Yql/Tor1a^tm2Yql
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Tor1a^tm2Yql mutation (0 available); any Tor1a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:130483 )

• on a beam-walking test, 71% of mice exhibit more falls than wild-type mice

• however, mice perform normally in a rotarod test

abnormal gait ( J:130483 )

• the hind base of male mice is smaller than in wild-type mice

hyperactivity ( J:130483 )

• mice exhibit hyperactivity in an open-field test

circling ( J:130483 )

increased stereotypic behavior ( J:130483 )

nervous system

nervous system phenotype ( J:130483 )

N	• the cerebral cortex and dopamine metabolite levels are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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