Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Allele Name: targeted mutation 1, Ari Waisman
• Allele ID: MGI:3772576
• Summary: 13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/? Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^tm1(HBEGF)Awai	involves: 129P2/OlaHsd * C57BL/6	MGI:3772814
cn2	Apc^Min/Apc^+ Dclk1^tm1.1(cre/ERT2)Seno/Dclk1^+ Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1(HBEGF)Awai	involves: 129S4/SvJaeSor * C57BL/6	MGI:5475206
cn3	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^tm9(CAG-tdTomato)Hze Oxt^tm1.1(cre)Dolsn/Oxt^+	involves: 129S6/SvEvTac * C57BL/6	MGI:5523454
cn4	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Kiss1r^tm1.1(cre)Uboe/Kiss1r^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5052333
cn5	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Kiss1^tm1.1(cre)Uboe/Kiss1^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5052334
cn6	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Opn4^tm1(cre)Sapa/Opn4^+	involves: 129S * C57BL/6	MGI:3803116
cn7	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^tm1(HBEGF)Awai Tg(Gdf9-icre)5092Coo/0	involves: C57BL/6	MGI:4430335
cn8	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^tm1(HBEGF)Awai Mog^tm1(cre)Gkl/?	involves: C57BL/6	MGI:3772815
cn9	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Tg(Mrgpra3-GFP/cre)#Xzd/0	involves: C57BL/6	MGI:5506548
cn10	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^tm1(HBEGF)Awai Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3772816
cn11	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Tg(Gh1-cre)bKnmn/0	involves: C57BL/6 * FVB/N	MGI:4943177
cn12	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Tg(Krt1-15-cre/PGR*)22Cot/0	involves: C57BL/6J * SJL/J	MGI:6118191
cn13	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Tg(Adora2a-cre)2MDkde/0	involves: C57BL/6 * SJL	MGI:3852518

Genotype
MGI:3772814

cn1

• Allelic Composition: Cd19^tm1(cre)Cgn/?; Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte morphology ( J:131076 )

• after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal lymphocyte cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent immature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal B cell morphology ( J:131076 )

• CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal splenic cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen

abnormal lymph node cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the lymph nodes

hematopoietic system

abnormal bone marrow cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal lymphocyte morphology ( J:131076 )

• after 3 or 7 days of diptheria toxin treatment, splenic B to T lymphocyte ratio decreases from 2.1 in controls to 0.6 and 0.3 respectively in double transgenic mice

abnormal lymphocyte cell number ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent immature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

absent mature B cells ( J:131076 )

• in bone marrow, drastic reductions in numbers of immature and mature B cells is observed

abnormal B cell morphology ( J:131076 )

• CD19-expressing B cells are absent after intraperitoneal injection of diptheria toxin for 7 days

abnormal splenic cell ratio ( J:131076 )

• with diptheria toxin treatment 3 times daily for 7 days, B cells are virtually absent from the spleen

Genotype
MGI:5475206

cn2

• Allelic Composition: Apc^Min/Apc⁺; Dclk1^{tm1.1(cre/ERT2)Seno}/Dclk1⁺; Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

neoplasm

abnormal tumor morphology ( J:193873 )

• after tamoxifen treatment and a single injection of diphtheria toxin (DT), polyps contain many Dclk1-positive apoptotic tumor cells and are severely injured or collapsed with Dclk1-negative polyps not displaying DT-induced apoptosis

digestive/alimentary system

digestive/alimentary phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, these cells are absent from the normal intestine with no significant damage to organ architecture observed in the intestine or stomach

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:193873 )

N • after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, no significant damage in organ architecture is observed in the pancreas or gallbladder

Genotype
MGI:5523454

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}; Oxt^{tm1.1(cre)Dolsn}/Oxt⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

growth/size/body

growth/size/body region phenotype ( J:192007 )

N • on a standard chow diet, 9 week-old mice given an injection of diphtheria toxin, with a second injection 1 week later, to ablate oxytocin-expressing neurons (lesioned mice), showed comparable body weight through 20 weeks of age

increased susceptibility to diet-induced obesity ( J:192007 )

♂ • when 9 week-old mice were given an injection of diphtheria toxin, with a second injection 1 week later, and maintained on a high fat diet following treatment, males displayed comparable body weight to controls up to 14 weeks of age, then develop higher body weight relative to controls at 22 weeks of age; in contrast, females show no difference in body weight compared to controls up to 22 weeks of age

adipose tissue

increased total body fat amount ( J:192007 )

• diphtheria toxin-treated males (lesioned) show significantly higher fat mass; lean masses are comparable

behavior/neurological

behavior/neurological phenotype ( J:192007 )

N • average daily food consumption measured over one week in control and lesioned (diphtheria toxin-treated) males are similar on normal chow and high fat diets

N • treatment of control and lesioned mice with MTII (melanocortin receptor agonist) reduced feeding in the dark to similar degrees in both cohorts

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:192007 )

♂ • when 9 week-old mice were given an injection of diphtheria toxin, with a second injection 1 week later, and maintained on a high fat diet following treatment, males displayed comparable body weight to controls up to 14 weeks of age, then develop higher body weight relative to controls at 22 weeks of age; in contrast, females show no difference in body weight compared to controls up to 22 weeks of age

decreased oxygen consumption ( J:192007 )

• lesioned mice on a high fat diet show lower oxygen consumption during a 2 day period of high fat diet, particularly during the dark cycle, compared to controls; during a 2 day period on normal chow diet, oxygen consumption is comparable between the two genotypes

decreased response to leptin ( J:192007 )

• after overnight fasting, leptin administration caused a 25% reduction in 2-hour feeding in lesioned mice and had no significant effect on 4- and 24-hour feeding whereas control mice treated with leptin showed a 25% decrease in 2- and 4-hour feeding and blunted 24-hour feeding by 20%

Genotype
MGI:5052333

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Kiss1r^{tm1.1(cre)Uboe}/Kiss1r⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

reproductive system

reproductive system phenotype ( J:173936 )

N • diphtheria-treated mice exhibit normal ovalutory cyclicity and fertility

nervous system

decreased neuron number ( J:173936 )

• diphtheria-treated mice exhibit ablation of Kiss1r+ and gonadotrophin-releasing hormone neurons

Genotype
MGI:5052334

cn5

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

reproductive system

abnormal estrous cycle ( J:173936 )

♀ • in diphtheria-treated mice

prolonged diestrus ( J:173936 )

♀ • in diphtheria-treated mice

prolonged estrus ( J:173936 )

♀ • in diphtheria-treated mice

female infertility ( J:173936 )

♀ • in diphtheria-treated mice

nervous system

decreased neuron number ( J:173936 )

• diphtheria-treated mice exhibit ablation of Kiss1+ neurons

Genotype
MGI:3803116

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Opn4^tm1(cre)Sapa/Opn4⁺
• Genetic Background: involves: 129S * C57BL/6

vision/eye

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

nervous system

abnormal suprachiasmatic nucleus morphology ( J:137151 )

• following treatment with diphtheria toxin, projections into the suprachiasmatic nucleus are reduced compared to in wild-type mice

decreased retina ganglion cell number ( J:137151 )

• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

behavior/neurological

behavior/neurological phenotype ( J:137151 )

N • despite ablation of melanopsin retinal ganglion cells following treatment with diphtheria toxin, mice exhibit normal image-forming visual responses

impaired pupillary reflex ( J:137151 )

• following treatment with diphtheria toxin, light pupilary reflex is lost

abnormal circardian behavior entrainment ( J:137151 )

• following treatment with diphtheria toxin, mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice

Genotype
MGI:4430335

cn7

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}; Tg(Gdf9-icre)5092Coo/0
• Genetic Background: involves: C57BL/6

cellular

abnormal female germ cell apoptosis ( J:157008 )

♀ • oocytes have undergone apoptosis in preantral follicles

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

reproductive system

abnormal female germ cell apoptosis ( J:157008 )

♀ • oocytes have undergone apoptosis in preantral follicles

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

abnormal ovary morphology ( J:157008 )

♀

abnormal ovarian follicle morphology ( J:157008 )

♀ • with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis

endocrine/exocrine glands

abnormal granulosa cell apoptosis ( J:157008 )

♀ • granulosa cells have undergone apoptosis in preantral follicles

abnormal ovary morphology ( J:157008 )

♀

abnormal ovarian follicle morphology ( J:157008 )

♀ • with diptheria toxin administration to 8-week-old pregnant females, oocytes and granulosa cells in preantral oocytes show apoptosis 9 days later, in contrast to treated controls where atretic follicles but not preantral follicles show apoptosis

Genotype
MGI:3772815

cn8

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}; Mog^tm1(cre)Gkl/?
• Genetic Background: involves: C57BL/6

growth/size/body

weight loss ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with weight loss after ~30 days

behavior/neurological

tremors ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with tremor after ~30 days

hindlimb paralysis ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with hindlimb paralysis after ~30 days

nervous system

increased neuron apoptosis ( J:131076 )

• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells

astrocytosis ( J:131076 )

• reactive astrogliosis is observed, as well as inflammatory cells, in oligodendrocytes after diptheria toxin injection 3 times daily for 7 days

abnormal neuron morphology ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, severe destruction of myelinated structures throughout the CNS is observed

demyelination ( J:131076 )

• diptheria toxin-induced demyelination is observed in treated double mutants

immune system

abnormal immune system physiology ( J:131076 )

• after diptheria toxin treatment for 7 days, low titers of IgM diptheria toxin-specific antibodies are detected in the serum; DT-specific IgG1 antibodies are detected later, and amounts are ~50-fold lower than in a typical hapten-induced antiboby response

cellular

increased neuron apoptosis ( J:131076 )

• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells

Genotype
MGI:5506548

cn9

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Tg(Mrgpra3-GFP/cre)#Xzd/0
• Genetic Background: involves: C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:197482 )

N • responses to acute noxious heat, cold, mechanical and chemical stimulation after diphtheria toxin (DTX) treatment are similar to control littermates

N • normal motor function is observed following DTX treatment

N • injection of capsaicin to the cheek induces normal pain-invoked facial wiping behavior in DTX-treated animals comparable to controls

N • cheek injection of beta-alanine induces robust scratching response in DTX-treated mice similar to the behavior in treated controls

nervous system

decreased sensory neuron number ( J:197482 )

integument

decreased pruritus ( J:197482 )

• scratching behavior is reduced relative to controls in DTX-treated mice after injection of alpha-methyl-serotonin or endothelin-1

• in models of dry skin pruritus and allergic chronic itch, DTX-treated mice show reduced scratching behavior compared to controls

• injection of chloroquine into cheeks of DTX-treated mice abolishes the hindpaw cheek-scratching elicited in DTX-treated controls

• hindpaw scratching induced by histamine administration to the cheek is reduced in DTX-treated mice relative to treated controls

• subcutaneous injection of histamine into the napes of DTX-treated mice results in a reduced scratching behavior compared to DTX-treated controls

• site-directed scratching is abolished in DTX-treated mutants following injection of either BAN8-22 or SLIGRL-NH2 (pruritogens that activate Mrgprx1)

• after subcutaneous cloroquine injection into the necks of DTX-treated mice, site-directed scratching is significantly reduced compared to DTX- and cholorquine-treated control littermates

Genotype
MGI:3772816

cn10

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

immune system

abnormal lymphocyte cell number ( J:131076 )

• following 3 days of diptheria toxin injection, splenic T to B lymphocyte ratio is reduced from a mean of 0.5 in controls to 0.1 in double mutant animals

decreased single-positive T cell number ( J:131076 )

• numbers of CD4+ and CD8+ T lymphocytes are ~equally decreased

hematopoietic system

abnormal lymphocyte cell number ( J:131076 )

• following 3 days of diptheria toxin injection, splenic T to B lymphocyte ratio is reduced from a mean of 0.5 in controls to 0.1 in double mutant animals

decreased single-positive T cell number ( J:131076 )

• numbers of CD4+ and CD8+ T lymphocytes are ~equally decreased

Genotype
MGI:4943177

cn11

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Tg(Gh1-cre)bKnmn/0
• Genetic Background: involves: C57BL/6 * FVB/N

homeostasis/metabolism

abnormal circulating hormone level ( J:169459 )

decreased circulating insulin level ( J:169459 )

• in diphtheria toxin-treated mice when a high-fat diet or a low-fat diet

decreased circulating insulin-like growth factor I level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

increased circulating leptin level ( J:169459 )

• in diphtheria toxin-treated mice

decreased circulating growth hormone level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

abnormal energy expenditure ( J:169459 )

decreased energy expenditure ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase or when mice are fed a high-fat diet

abnormal gas homeostasis ( J:169459 )

decreased oxygen consumption ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase

increased respiratory quotient ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

abnormal glucose homeostasis ( J:169459 )

decreased circulating glucose level ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow

• in diphtheria toxin-treated mice when fed a high-fat diet or a low-fat diet during an insulin tolerance test

impaired glucose tolerance ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

increased insulin sensitivity ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow, a high-fat diet, or a low-fat diet

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

endocrine/exocrine glands

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

adipose tissue

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

increased total body fat amount ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

increased retroperitoneal fat pad weight ( J:169459 )

• in diphtheria toxin-treated mice

growth/size/body

decreased lean body mass ( J:169459 )

• in diphtheria toxin-treated mice

decreased body weight ( J:169459 )

• in diphtheria toxin-treated mice fed a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

decreased liver weight ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

nervous system

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

behavior/neurological

decreased fluid intake ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

integument

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated growth hormone deficiency		DOID:0060870		J:169459

Genotype
MGI:6118191

cn12

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Tg(Krt1-15-cre/PGR*)22Cot/0
• Genetic Background: involves: C57BL/6J * SJL/J

digestive/alimentary system

abnormal esophageal epithelium morphology ( J:244536 )

• mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

cellular

increased cell proliferation ( J:244536 )

• mice treated with RU486 prior to diphtheria toxin injection exhibit reduced proliferation and atrophy in the esophageal epithelia compared with wild-type mice

Genotype
MGI:3852518

cn13

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Tg(Adora2a-cre)2MDkde/0
• Genetic Background: involves: C57BL/6 * SJL

behavior/neurological

enhanced conditioned place preference behavior ( J:150475 )

• in an amphetamine (1, 3 or 5 mg/kg) conditioned place preference (CPP) paradigm in mice with NAc deletion of dopamine receptor 2 (D₂R)-specific striatopallidal neurons, analysis of the extinction of CPP over 1 week showed that mutants maintained greater CPP on days 4 and 9 after last amphetamine injection whereas controls showed loss of CPP on day 9

hyperactivity ( J:150475 )

• at 6 days after bilateral full striatum diptheria toxin injection, mice show 3 to 4-fold higher activity in the open field; hyperactivity is stable through 16 days post-injection, with hyperactivity still apparent at 33 days

• however, deletion of D₂R-striatopallidal neurons in the nucleus accumbens (NAc) by injection of diptheria toxin does not result in spontaneous hyperlocomotion in the mice

nervous system

nervous system phenotype ( J:150475 )

N • mesostriatal dopaminergic system after ablation of striatopallidal neurons by diptheria toxin injection was not significantly different from controls in terms of dopamine extracellular concentration or amphetamine-induced dopamine overflow

abnormal basal ganglion morphology ( J:150475 )

• unilateral or bilateral diptheria toxin injection into the striatum causes unilateral or complete loss of dopamine receptor 2 (D₂R)-specific striatopallidal neurons at 14 days after injection; neuron loss was similar from the anterior to the posterior striatum

• dopamine receptor 1-specific neurons are unaffected and striatal interneuron populations remain intact