Phenotypes associated with this allele

• Allele Symbol: Tg(APOM)NCchr
• Allele Name: transgene insertion N, Christina Christoffersen
• Allele ID: MGI:3772656
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ldlr^tm1Her/Ldlr^tm1Her Tg(APOM)NCchr/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA	MGI:3772662
tg2	Tg(APOM)NCchr/0	B6.Cg-Tg(APOM)NCchr	MGI:3772661

Genotype
MGI:3772662

cx1

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APOM)NCchr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130647 )

• when fed a high cholesterol diet, mice exhibit a smaller plaque size compared to Ldlr^tm1Her homozygotes (neutral-lipid staining area is reduced by 39%, collagen staining area is reduced 30%)

• when fed a high cholesterol diet, en face lesion area in the aortic arch is 3.1+/-0.5% compared to 6.6+/-1.8% in Ldlr^tm1Her homozygotes

homeostasis/metabolism

decreased circulating triglyceride level ( J:130647 )

• 0.85+/-0.07 mmol/l compared to 1.11+/-0.10 mmol/l in Ldlr^tm1Her homozygotes at 4 weeks on a high cholesterol diet

abnormal cholesterol homeostasis ( J:130647 )

• when fed a high cholesterol diet, free cholesterol is decreased (0.31+/-0.02 nmol/mm² compared to 0.37+/-0.02 nmol/mm² in Ldlr^tm1Her homozygotes)

Genotype
MGI:3772661

tg2

• Allelic Composition: Tg(APOM)NCchr/0
• Genetic Background: B6.Cg-Tg(APOM)NCchr

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130647 )

N • mice exhibit normal cholesterol, triglyceride and phospholipids levels