Phenotypes associated with this allele

• Allele Symbol: Pafah2^tm1Arai
• Allele Name: targeted mutation 1, Hiroyuki Arai
• Allele ID: MGI:3772686
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pafah2^tm1Arai/Pafah2^tm1Arai	B6.129P2-Pafah2^tm1Arai	MGI:3772689

Genotype
MGI:3772689

hm1

• Allelic Composition: Pafah2^tm1Arai/Pafah2^tm1Arai
• Genetic Background: B6.129P2-Pafah2^tm1Arai

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

hepatic necrosis ( J:130728 )

• the degree of hepatic necrosis after treatment with CCl4 is increased compared to in wild-type mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:130728 )

• alanine transferase levels following treatment with CCL4 are increased compared to in wild-type mice

cellular

increased cellular sensitivity to oxidative stress ( J:130728 )

• mouse embryonic fibroblasts (MEFs) are more sensitive to oxidative stress induced by t-BuOOH than wild-type MEFs