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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		n-TUtca2tm2Mym
targeted mutation 2, Masayuki Yamamoto
MGI:3772692
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772771
cn2
 		Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3772772
cn3
 		Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:3772773


Genotype
MGI:3772771
cn1
Allelic
Composition		 n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:130723 )
• mice die between 1 and 3 months

cellular
increased cellular sensitivity to oxidative stress ( J:130723 )
• in culture, macrophages exhibit a 1.6-fold increase in intracellular reactive oxygen species levels at day 3 and a 2-fold increase at day 5 compared to in wild-type cells
increased apoptosis ( J:130723 )
• in culture, macrophage cell death increases from 6.2% in wild-type cells to 31%




Genotype
MGI:3772772
cn2
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (90 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to oxidative stress ( J:130723 )
• production of oxygen reactive species is increased compared to when either gene product is absent
increased cellular sensitivity to hydrogen peroxide ( J:130723 )
• sensitivity to hydrogen peroxide treatment is increased compared to when either gene product is absent
increased apoptosis ( J:130723 )
• in culture, macrophage cell death increases from 6.2% in wild-type cells and in Trsp null cells 31% to 53%




Genotype
MGI:3772773
cn3
Allelic
Composition		 Nfe2l2tm1Mym/Nfe2l2tm1Mym
Tg(Alb1-cre)1Dlr/0
n-TUtca2tm2Mym/n-TUtca2tm2.1Mym
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2l2tm1Mym mutation (5 available); any Nfe2l2 mutation (90 available)
n-TUtca2tm2.1Mym mutation (1 available); any n-TUtca2 mutation (2 available)
n-TUtca2tm2Mym mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(Alb1-cre)1Dlr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:130723 )
• the highest mortality rates occur at 3 weeks of age
premature death ( J:130723 )
• all mice die by 7 weeks with the highest mortality rates at 3 weeks of age

liver/biliary system
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice
abnormal hepatocyte morphology ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte necrosis not observed in either single mutants or wild-type mice
liver degeneration ( J:130723 )
• at 3 weeks of age, mice exhibit liver degeneration not observed in either single mutants or wild-type mice

homeostasis/metabolism

cellular
increased hepatocyte apoptosis ( J:130723 )
• at 3 weeks of age, mice exhibit hepatocyte apoptosis not observed in either single mutants or wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory