Analysis Tools|
Allele Symbol Allele Name Allele ID |
NamptGt(RRT307)Byg gene trap RRT307, BayGenomics MGI:3772777 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide
|
|
• fasted male mice exhibit decreased glucose levels compared to wild-type mice
|
|
• female mice exhibit impaired glucose tolerance compared to male mice and wild-type mice
• however, impaired glucose tolerance is reversed following administration of nicotinamind mononucleotide
|
|
• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/17/2024 MGI 6.24 |
|
|
|
||
