Analysis Tools|
Allele Symbol Allele Name Allele ID |
NamptGt(RRT307)Byg gene trap RRT307, BayGenomics MGI:3772777 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide
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• fasted male mice exhibit decreased glucose levels compared to wild-type mice
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• female mice exhibit impaired glucose tolerance compared to male mice and wild-type mice
• however, impaired glucose tolerance is reversed following administration of nicotinamind mononucleotide
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• female mice exhibit decreased insulin secretion 15 and 30 minutes after glucose injection unlike wild-type mice
• islet cells from female mice cultured in RPM1 media and 1 uM nicotinamide exhibit decreased insulin secretion in culture when stimulated with glucose compared to wild-type mice
• however, decreased insulin secretion is reversed following administration of nicotinamide mononucleotide
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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