All Phenotypes Tsix/Xist<tm3Sado> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tsix/Xist^tm3Sado
targeted mutation 3, Takashi Sado
MGI:3772875

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tsix/Xist^tm3Sado/Xist⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3772878

Allelic Composition	Tsix/Xist^tm3Sado/Xist⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix/Xist^tm3Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:130425 )

• when this allele is inherited paternally no XX female offsprings are observed 3 weeks after birth and only 1 XO female is produced although sex ratios are normal at E7.5

embryo

abnormal embryo development ( J:130425 )

• authors state that when this allele is inherited maternally, mice exhibit phenotypes associated with a failure of imprinted X-inactivation as in Xist^tm1Jae Tsix^tm1Enl heterozygotes

cellular

abnormal DNA methylation ( J:130425 )

• methylation at the Xist promoter is lost and histone modifications at the promoter are aberrant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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