About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Robo1tm1Wian
targeted mutation 1, William Andrews
MGI:3772898
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Robo1tm1Wian/Robo1tm1Wian involves: 129S/SvEv MGI:5754356
hm2
 		Robo1tm1Wian/Robo1tm1Wian involves: 129S/SvEv * C57BL/6 MGI:3772914


Genotype
MGI:5754356
hm1
Allelic
Composition		 Robo1tm1Wian/Robo1tm1Wian
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1tm1Wian mutation (0 available); any Robo1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
perimembraneous ventricular septal defect ( J:244438 )
• mice exhibit perimembranous VSDs at E18.5, just before birth




Genotype
MGI:3772914
hm2
Allelic
Composition		 Robo1tm1Wian/Robo1tm1Wian
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1tm1Wian mutation (0 available); any Robo1 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic/fetal subventricular zone morphology ( J:130430 )
• cell cultures of ganglionic eminence exhibit increased cell proliferation compared to wild-type cells
abnormal neurite morphology ( J:130430 )
• in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory