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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox4tm1Vlf
targeted mutation 1, Veronique Lefebvre
MGI:3773012
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sox4tm1Vlf/Sox4tm1Vlf involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3773014
cn2
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:5285375
cn3
Sox4tm1Vlf/Sox4tm1Vlf
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129 * C57BL/6 * CBA * SJL MGI:3773016
cn4
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Pou3f4-cre)32Cren/0
involves: 129 * C57BL/6 * CD-1 * FVB/N MGI:5285374
cn5
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL/J MGI:5285376
cn6
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285377
cn7
Sox11tm1.1Gan/Sox11tm1.1Gan
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5518648
cn8
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2 MGI:5518649
cn9
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4454341
cn10
Sox11tm1Weg/Sox11tm1Weg
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4454418
cn11
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4454420


Genotype
MGI:3773014
hm1
Allelic
Composition
Sox4tm1Vlf/Sox4tm1Vlf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice look and behave normally




Genotype
MGI:5285375
cn2
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• massive cell death in the branchial arches without a decrease in cell proliferation




Genotype
MGI:3773016
cn3
Allelic
Composition
Sox4tm1Vlf/Sox4tm1Vlf
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when treated with tamoxifen, mice die between E13.5 and E14.5 likely due to regurgitation of blood into the heart

cardiovascular system
• when treated with tamoxifen
• endocardial cushions form at the level of the semilunar valve but functional flaps do not form when treated with tamoxifen
• at E13.5, mice exhibit incomplete septation of the ventricles when treated with tamoxifen

homeostasis/metabolism
• at E13.5 when treated with tamoxifen




Genotype
MGI:5285374
cn4
Allelic
Composition
Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Pou3f4-cre)32Cren/0
Genetic
Background
involves: 129 * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Pou3f4-cre)32Cren mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• increased cell death without a decrease in cell proliferation

nervous system
• increased cell death without a decrease in cell proliferation




Genotype
MGI:5285376
cn5
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129 * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation

embryo
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation




Genotype
MGI:5285377
cn6
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

embryo
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation




Genotype
MGI:5518648
cn7
Allelic
Composition
Sox11tm1.1Gan/Sox11tm1.1Gan
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Gan mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Six3-cre)69Frty mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas

mortality/aging

vision/eye
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
• only a few cells present at E12.5
• impaired retinal ganglion cell development

growth/size/body

cellular
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5

nervous system
• only a few cells present at E12.5




Genotype
MGI:5518649
cn8
Allelic
Composition
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Six3-cre)69Frty/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Six3-cre)69Frty mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas

vision/eye
N
• mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells
• 2-fold increase starting at E14.5
• impaired retinal ganglion cell development
• reduced number of axon bundles in the retina
• in the inner nuclear layer and ganglion cell layer
• beginning at E16.5
• moderate at P0 and in adult mice

cellular
• 2-fold increase starting at E14.5
• reduced in retinal axon bundles

nervous system
• reduced in retinal axon bundles
• in the inner nuclear layer and ganglion cell layer
• beginning at E16.5
• moderate at P0 and in adult mice




Genotype
MGI:4454341
cn9
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Meibomian glands lack sympathetic innervation
• unable to fully open their eyes

nervous system
• have only a small rudiment of the stellate ganglion
• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
• musculus tarsalis of the eyelid lacks sympathetic innervation

endocrine/exocrine glands
• Meibomian glands lack sympathetic innervation

integument
• Meibomian glands lack sympathetic innervation




Genotype
MGI:4454418
cn10
Allelic
Composition
Sox11tm1Weg/Sox11tm1Weg
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1Weg mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• sympathetic ganglia are significantly smaller and have fewer cells at E11.5, E14.5 and E18.5
• expression analysis indicates a delay in noradrenergic differentiation in the sympathetic ganglia
• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5
• the number of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5r of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5




Genotype
MGI:4454420
cn11
Allelic
Composition
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• show mild reductions in size and cell number at E14.5 and are about two thirds the size of wild-type and have reduced cell numbers at E18.5
• expression analysis indicates a transient delay in noradrenergic differentiation in the sympathetic ganglia





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory