Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sox4tm1Vlf targeted mutation 1, Veronique Lefebvre MGI:3773012 |
||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
11 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• massive cell death in the branchial arches without a decrease in cell proliferation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when treated with tamoxifen, mice die between E13.5 and E14.5 likely due to regurgitation of blood into the heart
|
|
• when treated with tamoxifen
|
|
• endocardial cushions form at the level of the semilunar valve but functional flaps do not form when treated with tamoxifen
|
|
• at E13.5, mice exhibit incomplete septation of the ventricles when treated with tamoxifen
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased cell death without a decrease in cell proliferation
|
|
• increased cell death without a decrease in cell proliferation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation
|
|
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation
|
|
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas
|
• mice die before P14
|
|
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
|
|
• only a few cells present at E12.5
|
|
• decreased number
|
|
• impaired retinal ganglion cell development
|
|
• at E16.5
|
|
• at E14.5
|
|
• absent
|
|
• 6-fold increase starting at E14.5
• 10-fold increase starting at E16.5
|
|
• only a few cells present at E12.5
|
|
• decreased number
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Decrease in retinal ganglion cells in single Sox11tm1.1Gan and Sox4tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11tm1.1Gan/Sox11tm1.1Gan Sox4tm1Vlf/Sox4tm1Vlf Tg(Six3-cre)69Frty/0 retinas
| N |
• mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells
|
|
• 2-fold increase starting at E14.5
|
|
• thin
|
|
• impaired retinal ganglion cell development
|
|
• reduced number of axon bundles in the retina
|
|
• in the inner nuclear layer and ganglion cell layer
|
|
• beginning at E16.5
• moderate at P0 and in adult mice
|
|
• decreased number
|
|
• 2-fold increase starting at E14.5
|
|
• reduced in retinal axon bundles
|
|
• reduced in retinal axon bundles
|
|
• in the inner nuclear layer and ganglion cell layer
|
|
• beginning at E16.5
• moderate at P0 and in adult mice
|
|
• decreased number
|
|
• thin
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Meibomian glands lack sympathetic innervation
|
|
• unable to fully open their eyes
|
|
• have only a small rudiment of the stellate ganglion
|
|
• small rudiment
|
|
• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
|
|
• musculus tarsalis of the eyelid lacks sympathetic innervation
|
|
• Meibomian glands lack sympathetic innervation
|
|
• Meibomian glands lack sympathetic innervation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• sympathetic ganglia are significantly smaller and have fewer cells at E11.5, E14.5 and E18.5
|
|
• expression analysis indicates a delay in noradrenergic differentiation in the sympathetic ganglia
• sympathetic ganglia are almost devoid of proliferating cells at E11.5 and have a dramatic reduction at E12.5 but by E14.5 the absolute number of BrdU-labeled cells is only slightly lower than in the wild-type
when corrected for the decrease in size of the sympathetic ganglia, proliferation is increased relative to wild-type at E14.5 and E16.5
• the number of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5r of apoptotic cells in the sympathetic ganglia is increased 2.5 to 4 fold at E14.5 and E16.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• show mild reductions in size and cell number at E14.5 and are about two thirds the size of wild-type and have reduced cell numbers at E18.5
|
|
• expression analysis indicates a transient delay in noradrenergic differentiation in the sympathetic ganglia
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
