Phenotypes associated with this allele

• Allele Symbol: Ptgdr2^tm1Tasa
• Allele Name: targeted mutation 1, Takahiro Satoh
• Allele ID: MGI:3773068
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa	B6.129-Ptgdr2^tm1Tasa	MGI:5517583
hm2	Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa	C.129-Ptgdr2^tm1Tasa	MGI:3773073
hm3	Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa	involves: 129/Sv * BALB/c	MGI:3773072

Genotype
MGI:5517583

hm1

• Allelic Composition: Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa
• Genetic Background: B6.129-Ptgdr2^tm1Tasa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism

edema ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

Genotype
MGI:3773073

hm2

• Allelic Composition: Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa
• Genetic Background: C.129-Ptgdr2^tm1Tasa

immune system

decreased IgE level ( J:131146 )

• when chronically exposed to hapten, mice a 63% reduction in serum IgE levels compared to similarly treated wild-type mice

abnormal chemokine level ( J:131146 )

• 6 days after DNFB-challenge, mice exhibit reduced levels of macrophage-derived chemokine and Ccl5 compared to similarly treated wild-type mice

• mice exhibit higher levels of thymus- and actication-regulated chemokine compared to wild-type mice only in a few hours after DNFB-challenge

• however, cytokine production following challenge with DNFB is normal

abnormal inflammatory response ( J:131146 )

• during the very late phase response mice exhibit reduced numbers of lymphocytes, eosinophils, neutrophils and mast cells compared to similarly treated wild-type mice

• bsaophil infiltration during the very late phase response is reduced compared to in similarly treated wild-type mice

decreased inflammatory response ( J:131146 )

• ear-swelling in response to immunized with DNP-specific IgE and challenged with DNFB is reduced compared to in wild-type mice especially during the late phase response (reduced by 65%)

• 5 days following exposure to DNFB, mice exhibit less dermal infiltrate than wild-type mice

decreased susceptibility to type IV hypersensitivity reaction ( J:131146 )

• following exposure to FITC or repeated exposure to hapten, mice exhibit reduced acute and chronic contact hypersensitivity as determined by reduced swelling, basal ear thickness and serum IgE levels compared to wild-type mice

• however, Langerhans and dendritic cell migration is normal and mice respond normally to application of SRBC and croton oil (a causal agent of dermatitis)

homeostasis/metabolism

decreased prostaglandin level ( J:131146 )

• mice exhibit reduced levels of protoglandin D2 compared to wild-type mice in response to DNFB challenge

abnormal chemokine level ( J:131146 )

• 6 days after DNFB-challenge, mice exhibit reduced levels of macrophage-derived chemokine and Ccl5 compared to similarly treated wild-type mice

• mice exhibit higher levels of thymus- and actication-regulated chemokine compared to wild-type mice only in a few hours after DNFB-challenge

• however, cytokine production following challenge with DNFB is normal

hematopoietic system

decreased IgE level ( J:131146 )

• when chronically exposed to hapten, mice a 63% reduction in serum IgE levels compared to similarly treated wild-type mice

Genotype
MGI:3773072

hm3

• Allelic Composition: Ptgdr2^tm1Tasa/Ptgdr2^tm1Tasa
• Genetic Background: involves: 129/Sv * BALB/c

immune system

impaired eosinophil recruitment ( J:130892 )

• mice exhibit reduced eosinophil airway accumulation when exposed to poly I:C

• however, allergen-induced eosinophil accumulation in airways is normal

hematopoietic system

impaired eosinophil recruitment ( J:130892 )

• mice exhibit reduced eosinophil airway accumulation when exposed to poly I:C

• however, allergen-induced eosinophil accumulation in airways is normal