All Phenotypes Mavs<tm1Aki> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mavs^tm1Aki/Mavs^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:3773253
hm2	Mavs^tm1Aki/Mavs^tm1Aki	involves: 129S/SvEv * C57BL/6	MGI:5313730
hm3	Mavs^tm1Aki/Mavs^tm1Aki	involves: C57BL/6	MGI:3776850
hm4	Mavs^tm1Aki/Mavs^tm1Aki	Not Specified	MGI:3773164
cx5	Mavs^tm1Aki/Mavs^tm1Aki Ifna6^tm1Aki/Ifna6⁺	involves: 129P2/OlaHsd	MGI:3808911
cx6	Mavs^tm1Aki/Mavs^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:3773252
cx7	Ifih1^Rgsc422/Ifih1⁺ Mavs^tm1Aki/Mavs^tm1Aki	involves: C57BL/6JJcl * DBA/2JJcl	MGI:5617220
cx8	Ifih1^Rgsc422/Ifih1⁺ Mavs^tm1Aki/Mavs⁺	involves: C57BL/6JJcl * DBA/2JJcl	MGI:5617221

Allelic Composition	Mavs^tm1Aki/Mavs^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:130954 )

• exposure of mice or isolated spleen cells to ovalbumin and poly I:C results in half as many tetramer positive, ovalbumin-specific CD8+ as in wild-type mice

decreased IgG level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces 80% less IgG production than in wild-type mice

decreased IgG1 level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces 60% less IgG1 production than in wild-type mice

decreased IgG2a level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces severely less IgG2a production than in wild-type mice

decreased circulating interferon-alpha level ( J:130954 )

• exposure of mice to poly I:C results in reduced IFN-alpha serum levels compared to wild-type mice

decreased circulating interferon-beta level ( J:130954 )

• exposure of mice to poly I:C results in reduced IFN-beta serum levels compared to wild-type mice

decreased circulating interferon-gamma level ( J:130954 )

• immunization of spleen cells with class I antigens resulted in decreased interferon-gamma levels compared to in wild-type mice

decreased circulating interleukin-6 level ( J:130954 )

• exposure of mice to poly I:C results in reduced IL-6 serum levels compared to wild-type mice

decreased interferon-beta secretion ( J:130954 )

• exposure of dendritic cells to poly I:C results in abolishment of IFN-beta production compared to wild-type cells

decreased interleukin-12b secretion ( J:130954 )

• exposure of dendritic cells to poly I:C results in abolishment of IL-12b production compared to wild-type cells

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:130954 )

• exposure of mice to poly I:C results in reduced IFN-alpha serum levels compared to wild-type mice

decreased circulating interferon-beta level ( J:130954 )

• exposure of mice to poly I:C results in reduced IFN-beta serum levels compared to wild-type mice

decreased circulating interferon-gamma level ( J:130954 )

• immunization of spleen cells with class I antigens resulted in decreased interferon-gamma levels compared to in wild-type mice

decreased circulating interleukin-6 level ( J:130954 )

• exposure of mice to poly I:C results in reduced IL-6 serum levels compared to wild-type mice

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:130954 )

• exposure of mice or isolated spleen cells to ovalbumin and poly I:C results in half as many tetramer positive, ovalbumin-specific CD8+ as in wild-type mice

decreased IgG level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces 80% less IgG production than in wild-type mice

decreased IgG1 level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces 60% less IgG1 production than in wild-type mice

decreased IgG2a level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces severely less IgG2a production than in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:162888 )

• in mice infected with West Nile virus

immune system

immune system phenotype ( J:162888 )

N	• un-infected mice exhibit normal basal cytokine levels and regulatory T cell numbers

enlarged spleen ( J:162888 )

• massive in WNV-infected mice

increased dendritic cell number ( J:162888 )

• WNV-infected mice exhibit a 3-fold increase in pro-inflammatory dendritic cells in the draining popliteal lymph node compared with wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:162888 )

• in the draining popliteal lymph node of WNV-infected mice

decreased CD8-positive, alpha-beta T cell number ( J:162888 )

• in the draining popliteal lymph node of WNV-infected mice

increased IgG level ( J:162888 )

• in WNV-infected mice

increased IgG2a level ( J:162888 )

• 73-fold in WNV-infected mice on day 6

• 2-fold in WNV-infected mice on day 8

increased IgM level ( J:162888 )

• in WNV-infected mice

abnormal macrophage physiology ( J:162888 )

• macrophage from mice infected with West Nile virus exhibit increased virus replication compared with wild-type cells

abnormal circulating interferon level ( J:162888 )

• WNV-infected mice exhibit an increase in circulating type I IFN compared with wild-type mice

increased circulating interferon-gamma level ( J:162888 )

• in WNV-infected mice

increased circulating interleukin-6 level ( J:162888 )

• in WNV-infected mice

increased circulating tumor necrosis factor level ( J:162888 )

• in WNV-infected mice

abnormal dendritic cell physiology ( J:162888 )

• dendritic cells from West Nile virus (WNV)-infected mice sustain higher WNV replication compared with wild-type cells

decreased interferon-beta secretion ( J:162888 )

• absent in dendritic cells and macrophage from mice infected with West Nile virus

• decreased in neurons from mice infected with West Nile virus

CNS inflammation ( J:162888 )

• in the cortex, hippocampus and cerebellum of mice infected with West Nile virus

brain inflammation ( J:162888 )

• within the cortex, hippocampus, and cerebellum of WNV-infected mice with prominent perivascular and parenchymal infiltration

increased susceptibility to Flaviviridae infection ( J:162888 )

• mice infected with West Nile virus exhibit increased viremia, viral loads in the spleen and brain, tissue tropism to the kidney and spinal cord, neuron degeneration, central nervous system inflammation, circulating cytokines (type I IFN, IL6, TNF, CXCL10 and IFNG) and mortality compared with wild-type mice

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:162888 )

• in mice infected with West Nile virus

nervous system

CNS inflammation ( J:162888 )

• in the cortex, hippocampus and cerebellum of mice infected with West Nile virus

brain inflammation ( J:162888 )

• within the cortex, hippocampus, and cerebellum of WNV-infected mice with prominent perivascular and parenchymal infiltration

neuron degeneration ( J:162888 )

• damaged neurons in mice infected with WNV exhibit pyknosis, vacuolization, degeneration and cell dropout

abnormal neuron physiology ( J:162888 )

• neurons from mice infected with West Nile virus (WNV) exhibit increased virus replication and destruction of parenchyma and neurons (cortical and granular) compared with wild-type cells

homeostasis/metabolism

abnormal circulating interferon level ( J:162888 )

• WNV-infected mice exhibit an increase in circulating type I IFN compared with wild-type mice

increased circulating interferon-gamma level ( J:162888 )

• in WNV-infected mice

increased circulating interleukin-6 level ( J:162888 )

• in WNV-infected mice

increased circulating tumor necrosis factor level ( J:162888 )

• in WNV-infected mice

hematopoietic system

enlarged spleen ( J:162888 )

• massive in WNV-infected mice

increased dendritic cell number ( J:162888 )

• WNV-infected mice exhibit a 3-fold increase in pro-inflammatory dendritic cells in the draining popliteal lymph node compared with wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:162888 )

• in the draining popliteal lymph node of WNV-infected mice

decreased CD8-positive, alpha-beta T cell number ( J:162888 )

• in the draining popliteal lymph node of WNV-infected mice

increased IgG level ( J:162888 )

• in WNV-infected mice

increased IgG2a level ( J:162888 )

• 73-fold in WNV-infected mice on day 6

• 2-fold in WNV-infected mice on day 8

increased IgM level ( J:162888 )

• in WNV-infected mice

abnormal macrophage physiology ( J:162888 )

• macrophage from mice infected with West Nile virus exhibit increased virus replication compared with wild-type cells

growth/size/body

enlarged spleen ( J:162888 )

• massive in WNV-infected mice

Allelic Composition	Mavs^tm1Aki/Mavs^tm1Aki
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:132662 )

N	• the immunogenicity generated by a DNA vaccine is normal in these mice

Allelic Composition	Mavs^tm1Aki/Mavs^tm1Aki
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:124405 )

• serum IL-6 levels are decreased in mice exposed to poly I:C compared to wild-type mice

abnormal cytokine secretion ( J:124405 )

• mice exposed to encephalomyocarditis virus produce less IFN-beta, IFN-alpha, IL-6, IP-10 and MCP-1 compared to wild-type mice

• transfection of mouse embryonic fibroblasts (MEFs) with B-DNA results in reduced production of IFN-beta, IP-10 and IL-6 comapred to wild-type MEFs

decreased interferon-alpha secretion ( J:124405 )

• IFN-alpha in mouse embryonic fibroblast (MEFs) exposed to poly I:C is reduced compared to in wild-type MEFs

decreased interferon-beta secretion ( J:124405 )

• when mouse embryonic fibroblasts (MEFs) are exposed to dsRNA cells fail to produce INF-beta as do wild-type MEFs

• exposure of peritoneal macrophages (PECs) to encephalomyocarditis virus fails to induce the production of IFN-beta as in wild-type PECs

• IFN-beta in mouse embryonic fibroblast (MEFs) exposed to poly I:C is reduced compared to in wild-type MEFs

• IFN-beta production by mouse embryonic fibroblasts (MEFs) is decreased compared to in wild-type MEFs following exposure to modified vaccinia virus Ankara delta E3L

decreased interleukin-6 secretion ( J:124405 )

• IL-6 production in mouse embryonic fibroblast (MEFs) exposed to poly I:C is reduced compared to in wild-type MEFs

abnormal response to infection ( J:124405 )

• mouse embryonic fibroblasts (MEFs), peritoneal macrophages and granulocyte/macrophage colony-stimulating factor-generated bone-marrow derived dendritic cells infected with Newcastle disease virus, vesicular stomatitis virus lacking a variant of M proteins (NCP), and Sendai virus with mutated C proteins (Cm) produce less IFN-beta, IFN-alpha and IL-6 compared to infected wild-type MEFs

• when mouse embryonic fibroblasts (MEFs) are exposed to dsRNA cells fail to produce INF-beta as do wild-type MEFs

• exposure of peritoneal macrophages (PECs) to encephalomyocarditis virus fails to induce the production of IFN-beta as in wild-type PECs and IL-6 induction is reduced

• mice exposed to encephalomyocarditis virus produce less IFN-beta, IFN-alpha, IL-6, IP-10 and MCP-1 compared to wild-type mice

• transfection of mouse embryonic fibroblasts (MEFs) with B-DNA results in reduced production of IFN-beta, IP-10 and IL-6 compared to wild-type MEFs

increased susceptibility to Picornaviridae infection ( J:124405 )

• mice exhibit increased brain and liver titers and increased mortality compared to wild-type mice following exposure to encephalomyocarditis virus and vesicular stomatitis virus

• mice exposed to encephalomyocarditis virus produce less IFN-beta, IFN-alpha, IL-6, IP-10 and MCP-1 compared to wild-type mice

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:124405 )

• serum IL-6 levels are decreased in mice exposed to poly I:C compared to wild-type mice

Allelic Composition	Mavs^tm1Aki/Mavs^tm1Aki Ifna6^tm1Aki/Ifna6⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifna6^tm1Aki mutation (0 available); any Ifna6 mutation (16 available)
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal myeloid dendritic cell morphology ( J:124340 )

• GFP⁺ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection

abnormal macrophage morphology ( J:124340 )

• GFP⁺ macrophage numbers are significantly lower compared to controls after NDV infection

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

decreased interferon-alpha secretion ( J:124340 )

• levels of IFN-alpha are severely decreased 2 to 6 hours after infection with NDV compared to controls

• levels of IFN-alpha remain below what is found in controls for 24 hours after infection

hematopoietic system

abnormal myeloid dendritic cell morphology ( J:124340 )

• GFP⁺ conventional dendritic cell numbers are significantly lower compared to controls after NDV infection

abnormal macrophage morphology ( J:124340 )

• GFP⁺ macrophage numbers are significantly lower compared to controls after NDV infection

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

respiratory system

abnormal alveolar macrophage morphology ( J:124340 )

• GFP⁺ alveolar macrophage numbers are severely reduced after Newcastle disease virus (NDV) infection compared to controls

Allelic Composition	Mavs^tm1Aki/Mavs^tm1Aki Ticam1^tm1Aki/Ticam1^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)
Ticam1^tm1Aki mutation (0 available); any Ticam1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD8-positive, alpha-beta T cell number ( J:130954 )

• exposure of mice or isolated spleen cells to ovalbumin and poly I:C results no expansion of tetramer positive, ovalbumin-specific CD8+ as in wild-type mice

• however, interferon-gamma levels following exposure of spleen cells to ovalbumin in alum plus CpG DNA results in a normal numbers of tetramer positive, ovalbumin-specific CD8+ T cells

decreased IgG level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG production unlike in wild-type mice

decreased IgG1 level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG1 production unlike in wild-type mice

decreased IgG2a level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG2a production unlike in wild-type mice

decreased cytotoxic T cell cytolysis ( J:130954 )

• following immunization with ovalbumin in alum plus poly I:C do not exhibit cytotoxicity unlike in wild-type mice

decreased circulating interferon-alpha level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IFN-alpha serum levels unlike in wild-type mice

decreased circulating interferon-beta level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IFN-beta serum levels unlike in wild-type mice

decreased circulating interferon-gamma level ( J:130954 )

• immunization of spleen cells with class I antigens resulted in no increase in interferon-gamma levels as in wild-type mice

• however, interferon-gamma levels following exposure of spleen cells to ovalbumin in alum plus CpG DNA results in a normal interferon-gamma response

decreased circulating interleukin-12b level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IL-12b serum levels unlike in wild-type mice

decreased circulating interleukin-6 level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IL-6 serum levels unlike in wild-type mice

decreased interferon-beta secretion ( J:130954 )

• exposure of dendritic cells to poly I:C results in reduction of IFN-beta production compared to wild-type cells

decreased interleukin-12b secretion ( J:130954 )

• exposure of dendritic cells to poly I:C results in reduction of IL-12b production compared to wild-type cells

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IFN-alpha serum levels unlike in wild-type mice

decreased circulating interferon-beta level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IFN-beta serum levels unlike in wild-type mice

decreased circulating interferon-gamma level ( J:130954 )

• immunization of spleen cells with class I antigens resulted in no increase in interferon-gamma levels as in wild-type mice

• however, interferon-gamma levels following exposure of spleen cells to ovalbumin in alum plus CpG DNA results in a normal interferon-gamma response

decreased circulating interleukin-12b level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IL-12b serum levels unlike in wild-type mice

decreased circulating interleukin-6 level ( J:130954 )

• exposure of mice to poly I:C results in no increase in IL-6 serum levels unlike in wild-type mice

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:130954 )

• exposure of mice or isolated spleen cells to ovalbumin and poly I:C results no expansion of tetramer positive, ovalbumin-specific CD8+ as in wild-type mice

• however, interferon-gamma levels following exposure of spleen cells to ovalbumin in alum plus CpG DNA results in a normal numbers of tetramer positive, ovalbumin-specific CD8+ T cells

decreased IgG level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG production unlike in wild-type mice

decreased IgG1 level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG1 production unlike in wild-type mice

decreased IgG2a level ( J:130954 )

• exposure of mice to ovalbumin and poly I:C induces no increase in IgG2a production unlike in wild-type mice

decreased cytotoxic T cell cytolysis ( J:130954 )

• following immunization with ovalbumin in alum plus poly I:C do not exhibit cytotoxicity unlike in wild-type mice

Allelic Composition	Ifih1^Rgsc422/Ifih1⁺ Mavs^tm1Aki/Mavs^tm1Aki
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1^Rgsc422 mutation (0 available); any Ifih1 mutation (45 available)
Mavs^tm1Aki mutation (0 available); any Mavs mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:209917 )

N	• mice do not develop glomerulonephritis, enhanced expression of cytokines and chemokines or increased numbers of immune cells in the spleen, unlike mice wild-type for Mavs

Allelic Composition	Ifih1^Rgsc422/Ifih1⁺ Mavs^tm1Aki/Mavs⁺
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

glomerulonephritis ( J:209917 )

• less severe than in mice wild-type for Mavs

renal/urinary system

glomerulonephritis ( J:209917 )

• less severe than in mice wild-type for Mavs

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