Phenotypes associated with this allele

• Allele Symbol: Pbx3^tm1Og
• Allele Name: targeted mutation 1, Stephen O'Gorman
• Allele ID: MGI:3773271
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hoxb1^tm1(cre)Og/Hoxb1^+ Pbx3^tm1Og/Pbx3^tm1Og	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:3773313

Genotype
MGI:3773313

cn1

• Allelic Composition: Hoxb1^tm1(cre)Og/Hoxb1⁺; Pbx3^tm1Og/Pbx3^tm1Og
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:130927 )

• by 8 months of age mice exhibit difficulty feeding and grooming resulting in poor overall health

improved righting response ( J:130927 )

hyporesponsive to tactile stimuli ( J:130927 )

• mice exhibit a decreased response to touch sensation in a sticky tape assay

increased startle reflex ( J:130927 )

limb grasping ( J:130927 )

• while mice initially splay limbs when held by the tail they then rapidly clasp both fore- and hindlimbs

impaired coordination ( J:130927 )

• mice exhibit impaired performance on a rotarod test at 4 and 8 weeks of age with decline in performance between 4 and 8 weeks compared to wild-type mice

abnormal limb posture ( J:130927 )

• at 4 weeks of age, mice display splaying of the hindlimbs and extensor posturing of the limbs and tail at rest and lifting of the forelimbs that result in forelimbs being elevated above the surface for greater than 20 seconds

• by 10 weeks of age mice consistently maintain elevated hindlimbs

abnormal locomotor coordination ( J:130927 )

• although mice maintain a normal gait their hindlimb placement is wider than in wild-type mice

• by 4 months of age widening hindlimb placement results in dragging the belly while walking

bradykinesia ( J:130927 )

• at 4 weeks of age

decreased thermal nociceptive threshold ( J:130927 )

nervous system

abnormal neuron morphology ( J:130927 )

• at 2 weeks, cutaneous sensory afferents exhibit abnormally thickened fascicles that form thick cords in more lateral regions of the dorsal horn than in wild-type mice

abnormal neuron differentiation ( J:130927 )

• by E15, mice exhibit abnormally superficial positioning of Meis+ glutamanergic neurons and the number of calbindin+ neurons is increased 3-fold compared to in wild-type mice

decreased neuron number ( J:130927 )

• the superficial dorsal horn has 30% fewer neurons than in wild-type mice and neuron loss is not restricted to a single class of neurons

abnormal spinal cord dorsal horn morphology ( J:130927 )

• the cross-sectional area of the dorsal horn at C8 is smaller than in wild-type mice

• mice exhibit atrophy in the dorsal horn

• the superficial laminae of the dorsal horn is thin compared to in wild-type mice

• the superficial dorsal horn has 30% fewer neurons than in wild-type mice

• at 2 weeks, cutaneous sensory afferents exhibit abnormally thickened fascicles that form thick cords in more lateral regions of the dorsal horn than in wild-type mice

• however, at P15 the dorsal root ganglia appears normal

growth/size/body

decreased body size ( J:130927 )

• at 2 weeks of age mice are smaller than wild-type mice

cellular

abnormal neuron differentiation ( J:130927 )

• by E15, mice exhibit abnormally superficial positioning of Meis+ glutamanergic neurons and the number of calbindin+ neurons is increased 3-fold compared to in wild-type mice