Phenotypes associated with this allele

• Allele Symbol: Igh^{tm1(VH558)Mss}
• Allele Name: targeted mutation 1, Mark S Schlissel
• Allele ID: MGI:3773307
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1(VH558)Mss/Igh^tm1(VH558)Mss	involves: FVB/N	MGI:3773309
ht2	Igh^tm1(VH558)Mss/Igh^+	involves: FVB/N	MGI:3773311

Genotype
MGI:3773309

hm1

• Allelic Composition: Igh^{tm1(VH558)Mss}/Igh^{tm1(VH558)Mss}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:130421 )

• the knock-in gene segment rearranges at a higher frequency than the endogenous gene segment during VDJ recombination

• the order of recombination where D segments recombine to J segments and then V recombines with the DJ segments is lost in these mutant mice

hematopoietic system

abnormal B cell differentiation ( J:130421 )

• the knock-in gene segment rearranges at a higher frequency than the endogenous gene segment during VDJ recombination

• the order of recombination where D segments recombine to J segments and then V recombines with the DJ segments is lost in these mutant mice

Genotype
MGI:3773311

ht2

• Allelic Composition: Igh^{tm1(VH558)Mss}/Igh⁺
• Genetic Background: involves: FVB/N

immune system

abnormal B cell differentiation ( J:130421 )

• the allelic exclusion of B cells for IgH is lost in these mice

hematopoietic system

abnormal B cell differentiation ( J:130421 )

• the allelic exclusion of B cells for IgH is lost in these mice