Analysis Tools|
Allele Symbol Allele Name Allele ID |
Scd1tm2Ntam targeted mutation 2, James M Ntambi MGI:3773308 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• decreased hair shaft
|
|
• loss of matrix progenitors
|
|
• loss of dermal papilla cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity
|
|
• reduced by 51% in mice on a high-sucrose very low-fat diet compared to diet matched controls
|
|
• on a high carbohydrate diet weights of the gonadal, retroperitioneal, and inguinal fat pads are reduced by about 49% - 59% compared to controls lacking the cre transgene
|
|
• reduced weight on a high carbohydrate diet compared to diet matched controls
|
|
• reduced weight on a high carbohydrate diet compared to diet matched controls
|
|
• reduced weight on a high carbohydrate diet compared to diet matched controls
|
| N |
• unlike global null mice, no difference is seen in plasma glucose and insulin levels, glucose clearance or insulin sensitivity between liver knockout mice and controls on a high carbohydrate diet
|
|
• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity
|
|
• reduced in mice on a high-sucrose very low-fat diet compared to diet matched controls
• but not in mice on high carbohydrate, high fat, or chow diet
• supplementing the high-sucrose very low-fat diet with oleate prevents the decrease in plasma glucose levels
|
|
• impaired production of glucose from pyruvate in mice fed a high-sucrose very low-fat diet
|
|
• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls
• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels
|
|
• 85% decrease in hepatic lipogenesis in mice on a high carbohydrate diet
• however, cholesterol synthesis is unaffected
|
|
• develops in mice on a high-sucrose very low-fat diet, probably due to increases in HDL and LDL cholesterol
|
|
• in mice on a high carbohydrate diet compared to diet-matched controls
• however, levels are similar to controls in mice on a chow or high fat diet
|
|
• significant reduction in mice on a high carbohydrate or a high-sucrose very low-fat diet compared to diet-matched controls
|
|
• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls
• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate
• supplementing the diet with triolein reduces the decrease in liver triglyceride levels
|
|
• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls
• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels
|
|
• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls
• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate
• supplementing the diet with triolein reduces the decrease in liver triglyceride levels
|
|
• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced fatty liver development
|
|
• block in carbohydrate-induce hepatic lipogenesis
• a high-sucrose very low-fat diet fails to increase the rate of triglyceride secretion, unlike in controls
|
| N |
• unlike global null mice, no difference in food intake is seen in mice on a chow diet
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
