Analysis Tools|
Allele Symbol Allele Name Allele ID |
Prkar2btm2Gsm targeted mutation 2, G Stanley McKnight MGI:3773428 |
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| Summary |
12 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female percentage body fat is reduced by about a third
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• locomotor activity is 1.5 to 2-fold that of wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• percentage body fat in females is reduced by about 25%
• percentage body fat in males is reduced by about 14%
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• mice are slightly hyperphagic
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• leptin level are reduced by about 60%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• hyperactivity phenotype is reversed
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| N |
• lean body mass is similar to controls
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| N |
• fat pad weights are similar to controls
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| N |
• serum leptin levels similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hyper-locomotor activity is retained
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• reproductive fat pads weigh significantly less in both males and females
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• low serum leptin levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locomotor behavior comparable to controls
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• lean body weight remains low
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• serum leptin levels remain low
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• remain hyperactive
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| N |
• body weight similar to controls
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| N |
• adiposity similar to controls
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| N |
• serum leptin levels similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locomotor behavior restored to normal
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| N |
• body weight restored to normal
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| N |
• major fat pads are comparable to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• hyperactivity phenotype is reduced
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| N |
• body weight similar to controls
• lean body mass is similar to controls
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| N |
• adiposity similar to controls
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| N |
• serum leptin levels similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• hyperactivity phenotype is lost
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• low adiposity
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• low body weight
• lean body
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• low serum leptin levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• locomotor behavior restored to normal
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| N |
• body weight restored to normal
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| N |
• major fat pads are comparable to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• female mice have a 2-fold gain in mg of BAT compared to littermate controls
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• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls
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• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
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• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
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• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls
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| N |
• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the Ay mutant allele
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• locomotor activity is about 1.5-fold higher compared to wild-type control mice
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| N |
• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the Ay mutant allele
• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the Ay mutant allele
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• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age
• rate of weight gain in male mice is significantly less than in Ay heterozygotes
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• mice have a yellow coat color
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• mice have a yellow coat color
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have increased percentage of body fat but is 10% less than what is observed in Ay heterozygotes
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• mice have a higher food consumption but is about 10% less than the amount Ay heterozygotes consume
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• mice have increased rate of weight growth compared to wild-type mice but significantly less than in Ay heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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