Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tead1tm1Hssk targeted mutation 1, Hiroshi Sasaki MGI:3773642 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die around E11.5, although some die even earlier
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• reduction of myocardium trabeculation
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• reduction of myocardium trabeculation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit smaller posterior tissues
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• defective embryonic turning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes
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• embryos develop a posterior-ventral protrusion
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• embryos develop a bulbous allantois
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants are developmentally delayed but resemble normal E8.5 embryos
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• mutants are developmentally delayed but resemble normal E8.5 embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die at E9.5
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• embryos are slightly smaller at E7.5 and small at E8.5
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• cell apoptosis is increased in E7.75 embryos
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• mutants fail to undergo embryonic turning at E8.75
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• embryos are slightly smaller at E7.5 and small at E8.5
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• an abnormal protrusion to the ventral side develops at the posterior end of the mutant embryo at E8.75, with abnormal cell accumulation in this region
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• marker analysis indicates that development of the posterior definitive endoderm is partially compromised
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• lateral plate mesoderm is displaced toward the lateral margins
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• paraxial mesoderm is displaced toward the lateral margins
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• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated
• neural plate is kinked dorso-ventrally at E8.75
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• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5
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• marker analysis indicates defects in notochordal development
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• E8.5 embryos lack a notochord
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• no morphologically identifiable somites form
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• embryos are highly disorganized at E9.5, and typically develop a posterior-ventral protrusion
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• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective
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• E9.5 embryos develop a bulbous allantois
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• E9.5 embryos develop a bulbous allantois that fails to fuse with the chorion
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• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective
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• the anterior region is dorsally folded and there are two heart tubes at E8.5, indicating that the two heart primordia failed to fuse
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• cell apoptosis is increased in E7.75 embryos
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• cell proliferation is reduced in E7.75 embryos
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• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated
• neural plate is kinked dorso-ventrally at E8.75
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• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5
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• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5
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• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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