Phenotypes associated with this allele

• Allele Symbol: Tead2^tm1Hssk
• Allele Name: targeted mutation 1, Hiroshi Sasaki
• Allele ID: MGI:3773644
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tead2^tm1Hssk/Tead2^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797236
cx2	Tead1^tm1Hssk/Tead1^+ Tead2^tm1Hssk/Tead2^tm1Hssk Yap1^tm1Smil/Yap1^+	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797240
cx3	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2^+ Yap1^tm1Smil/Yap1^+	either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)	MGI:3797243
cx4	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2^+	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797239
cx5	Tead1^tm1Hssk/Tead1^tm1Hssk Tead2^tm1Hssk/Tead2^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797237
cx6	Tead1^tm1Hssk/Tead1^+ Tead2^tm1Hssk/Tead2^tm1Hssk	either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)	MGI:3797238
cx7	Sox11^tm1.2Vlf/Sox11^+ Sox4^tm1.1Vlf/Sox4^+ Tead2^tm1Hssk/Tead2^tm1Hssk	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5285372

Genotype
MGI:3797236

hm1

• Allelic Composition: Tead2^tm1Hssk/Tead2^tm1Hssk
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131426 )

• mice exhibit no overt abnormalities and are fertile

Genotype
MGI:3797240

cx2

• Allelic Composition: Tead1^tm1Hssk/Tead1⁺; Tead2^tm1Hssk/Tead2^tm1Hssk; Yap1^tm1Smil/Yap1⁺
• Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

embryo

abnormal developmental patterning ( J:131426 )

• mutants exhibit smaller posterior tissues

abnormal embryo turning ( J:131426 )

• defective embryonic turning

Genotype
MGI:3797243

cx3

• Allelic Composition: Tead1^tm1Hssk/Tead1^tm1Hssk; Tead2^tm1Hssk/Tead2⁺; Yap1^tm1Smil/Yap1⁺
• Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

embryo

abnormal embryo development ( J:131426 )

• mutants show essentially the same morphological defects as double Tead1 and Tead2 homozygotes

abnormal embryonic tissue morphology ( J:131426 )

• embryos develop a posterior-ventral protrusion

abnormal allantois morphology ( J:131426 )

• embryos develop a bulbous allantois

Genotype
MGI:3797239

cx4

• Allelic Composition: Tead1^tm1Hssk/Tead1^tm1Hssk; Tead2^tm1Hssk/Tead2⁺
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

embryo

embryonic growth retardation ( J:131426 )

• mutants are developmentally delayed but resemble normal E8.5 embryos

growth/size/body

embryonic growth retardation ( J:131426 )

• mutants are developmentally delayed but resemble normal E8.5 embryos

Genotype
MGI:3797237

cx5

• Allelic Composition: Tead1^tm1Hssk/Tead1^tm1Hssk; Tead2^tm1Hssk/Tead2^tm1Hssk
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131426 )

• die at E9.5

growth/size/body

decreased embryo size ( J:131426 )

• embryos are slightly smaller at E7.5 and small at E8.5

embryo

increased embryonic tissue cell apoptosis ( J:131426 )

• cell apoptosis is increased in E7.75 embryos

abnormal developmental patterning ( J:131426 )

failure of initiation of embryo turning ( J:131426 )

• mutants fail to undergo embryonic turning at E8.75

decreased embryo size ( J:131426 )

• embryos are slightly smaller at E7.5 and small at E8.5

abnormal embryonic tissue morphology ( J:131426 )

• an abnormal protrusion to the ventral side develops at the posterior end of the mutant embryo at E8.75, with abnormal cell accumulation in this region

abnormal posterior definitive endoderm morphology ( J:131426 )

• marker analysis indicates that development of the posterior definitive endoderm is partially compromised

abnormal lateral plate mesoderm morphology ( J:131426 )

• lateral plate mesoderm is displaced toward the lateral margins

abnormal paraxial mesoderm morphology ( J:131426 )

• paraxial mesoderm is displaced toward the lateral margins

abnormal neural plate morphology ( J:131426 )

• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated

• neural plate is kinked dorso-ventrally at E8.75

open neural tube ( J:131426 )

• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5

abnormal notochord morphology ( J:131426 )

• marker analysis indicates defects in notochordal development

absent notochord ( J:131426 )

• E8.5 embryos lack a notochord

absent somites ( J:131426 )

• no morphologically identifiable somites form

disorganized embryonic tissue ( J:131426 )

• embryos are highly disorganized at E9.5, and typically develop a posterior-ventral protrusion

abnormal extraembryonic tissue morphology ( J:131426 )

abnormal vitelline vasculature morphology ( J:131426 )

• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective

abnormal allantois morphology ( J:131426 )

• E9.5 embryos develop a bulbous allantois

failure of chorioallantoic fusion ( J:131426 )

• E9.5 embryos develop a bulbous allantois that fails to fuse with the chorion

cardiovascular system

abnormal vitelline vasculature morphology ( J:131426 )

• in the yolk sac, specification of both endothelia and erythroblasts occurs, but their development into an organized primitive vascular plexus is defective

abnormal heart tube morphology ( J:131426 )

• the anterior region is dorsally folded and there are two heart tubes at E8.5, indicating that the two heart primordia failed to fuse

cellular

increased embryonic tissue cell apoptosis ( J:131426 )

• cell apoptosis is increased in E7.75 embryos

decreased cell proliferation ( J:131426 )

• cell proliferation is reduced in E7.75 embryos

nervous system

abnormal neural plate morphology ( J:131426 )

• the neural plate remains flat and the boundary between the neuroectoderm and the underlying mesoderm is not clearly demarcated

• neural plate is kinked dorso-ventrally at E8.75

open neural tube ( J:131426 )

• in the central region, the neural plate has not fused along the dorsal ridges to form a neural tube at E8.5

Genotype
MGI:3797238

cx6

• Allelic Composition: Tead1^tm1Hssk/Tead1⁺; Tead2^tm1Hssk/Tead2^tm1Hssk
• Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

nervous system

incomplete rostral neuropore closure ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

exencephaly ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

embryo

incomplete rostral neuropore closure ( J:131426 )

• half of the mutants show an anterior neural tube closure defect or exencephaly between E9.5 and E15.5

Genotype
MGI:5285372

cx7

• Allelic Composition: Sox11^tm1.2Vlf/Sox11⁺; Sox4^tm1.1Vlf/Sox4⁺; Tead2^tm1Hssk/Tead2^tm1Hssk
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

cardiovascular system

double outlet right ventricle ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

ventricular septal defect ( J:175338 )

• higher incident than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes

embryo

abnormal notochord morphology ( J:175338 )

• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice

skeleton

abnormal vertebrae morphology ( J:175338 )

• more severe and more frequent than in Tead2^tm1Hssk homozygotes and Sox4^tm1.1Vlf Sox11^tm2.2Weg heterozygotes