Phenotypes associated with this allele

• Allele Symbol: Foxp3^tm1.1Mal
• Allele Name: targeted mutation 1.1, Bernard Malissen
• Allele ID: MGI:3773675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxp3^tm1.1Mal/Foxp3^tm1.1Mal Lat^tm1.1Mal/Lat^tm1.1Mal	involves: 129S2/SvPas * C57BL/6	MGI:3807552

Genotype
MGI:3807552

cx1

• Allelic Composition: Foxp3^tm1.1Mal/Foxp3^tm1.1Mal; Lat^tm1.1Mal/Lat^tm1.1Mal
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:131351 )

♀ • thymus size is reduced by 2.6-fold compared to controls

decreased regulatory T cell number ( J:131351 )

♀ • absolute numbers Foxp3⁺ regulatory T cells are reduced by 1.5 fold in the spleen and 3 fold in the thymus

♀ • these regulatory T cells also have reduced or no expression of CD25

abnormal regulatory T cell physiology ( J:131351 )

♀ • Foxp3⁺ CD4⁺ regulatory T cells fail to suppress TCR-induced proliferation of wild-type CD4⁺ T cells

hematopoietic system

thymus hypoplasia ( J:131351 )

♀ • thymus size is reduced by 2.6-fold compared to controls

decreased regulatory T cell number ( J:131351 )

♀ • absolute numbers Foxp3⁺ regulatory T cells are reduced by 1.5 fold in the spleen and 3 fold in the thymus

♀ • these regulatory T cells also have reduced or no expression of CD25

abnormal regulatory T cell physiology ( J:131351 )

♀ • Foxp3⁺ CD4⁺ regulatory T cells fail to suppress TCR-induced proliferation of wild-type CD4⁺ T cells

endocrine/exocrine glands

thymus hypoplasia ( J:131351 )

♀ • thymus size is reduced by 2.6-fold compared to controls