immune system
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• thymus size is reduced by 2.6-fold compared to controls
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• absolute numbers Foxp3+ regulatory T cells are reduced by 1.5 fold in the spleen and 3 fold in the thymus
• these regulatory T cells also have reduced or no expression of CD25
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• Foxp3+ CD4+ regulatory T cells fail to suppress TCR-induced proliferation of wild-type CD4+ T cells
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hematopoietic system
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• thymus size is reduced by 2.6-fold compared to controls
|
|
• absolute numbers Foxp3+ regulatory T cells are reduced by 1.5 fold in the spleen and 3 fold in the thymus
• these regulatory T cells also have reduced or no expression of CD25
|
|
• Foxp3+ CD4+ regulatory T cells fail to suppress TCR-induced proliferation of wild-type CD4+ T cells
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endocrine/exocrine glands
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• thymus size is reduced by 2.6-fold compared to controls
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