Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Jlw
• Allele Name: targeted mutation 1, Jennifer L Whistler
• Allele ID: MGI:3773695
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Jlw/Oprm1^tm1Jlw	involves: 129P2/OlaHsd	MGI:3807577

Genotype
MGI:3807577

hm1

• Allelic Composition: Oprm1^tm1Jlw/Oprm1^tm1Jlw
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to addictive substance ( J:131412 )

• mice do not buildup a tolerance to morphine either acutely or chronically

• morphine effectiveness in blocking pain is unimpaired in mice that 24 hours previously received a very high dose of morphine while morphine loses half of its effectiveness in wild-type mice treated the same way

• morphine loses little effectiveness in blocking pain in mice chronically treated with morphine for 5 days instead of the 75% loss of effectiveness observed in wild-type mice

• mice have significantly less withdrawal symptoms than wild-type mice after injection of an opioid antagonist following 5 days of morphine administration

increased chemically-elicited antinociception ( J:131412 )

• a dose of 3 mg/kg bodyweight of morphine is as effective as a 10mg/kg dose in wild-type mice in hot-plate response latency test

• this enhanced antinociception is observed for at least 300 minutes after administration of morphine