About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glipr1tm1Tt
targeted mutation 1, Timothy C Thompson
MGI:3773696
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glipr1tm1Tt/Glipr1tm1Tt Not Specified MGI:3807669
ht2
 		Glipr1tm1Tt/Glipr1+ Not Specified MGI:3807668
cx3
 		Glipr1tm1Tt/Glipr1+
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd MGI:3807670
cx4
 		Glipr1tm1Tt/Glipr1tm1Tt
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd MGI:3807671


Genotype
MGI:3807669
hm1
Allelic
Composition		 Glipr1tm1Tt/Glipr1tm1Tt
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to alkylating agents ( J:131419 )
• embryonic fibroblasts have reduced levels of apoptosis when treated with DNA damaging agents compared to wild-type embryonic fibroblasts

neoplasm
increased tumor incidence ( J:131419 )
• 10 out of 24 mice develop tumors compared to 1 out of 16 in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807668
ht2
Allelic
Composition		 Glipr1tm1Tt/Glipr1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 16 out of 40 mice develop tumors compared to 1 out of 16 in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807670
cx3
Allelic
Composition		 Glipr1tm1Tt/Glipr1+
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 59 out of 104 mice develop tumors compared to 31 out of 63 mice in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Genotype
MGI:3807671
cx4
Allelic
Composition		 Glipr1tm1Tt/Glipr1tm1Tt
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glipr1tm1Tt mutation (0 available); any Glipr1 mutation (17 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:131419 )
• 45 out of 74 mice develop tumors compared to 31 out of 63 mice in littermate controls
• tumors differ in their type and location, and include lymphomas, sarcomas, plasmacytomas and others




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory