All Phenotypes Ednra<tm3(Ednrb)Hku> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ednra^{tm3(Ednrb)Hku}
targeted mutation 3, Hiroki Kurihara
MGI:3773700

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796527
ht2	Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796526
ht3	Ednra^tm1Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796529
ht4	Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3836980

Allelic Composition	Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

Allelic Composition	Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm2.1Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

Allelic Composition	Ednra^tm1Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm1Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

Allelic Composition	Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm2Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )

skeleton

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24