All Phenotypes Ednra<tm3(Ednrb)Hku> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ednra^{tm3(Ednrb)Hku}
targeted mutation 3, Hiroki Kurihara
MGI:3773700

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796527
ht2	Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796526
ht3	Ednra^tm1Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3796529
ht4	Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku}	involves: 129 * C57BL/6 * ICR	MGI:3836980

Allelic Composition	Ednra^{tm3(Ednrb)Hku}/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis at E18.5

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone or separated from basisphenoid

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• abnormalities similar to Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku} compound mutants at E18.5

• mice have relatively well-developed incisive alveolus

Allelic Composition	Ednra^tm2.1Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm2.1Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

skeleton

abnormal craniofacial bone morphology ( J:131382 )

• ectopic cartilage appears between malleal/incal region and the extended basitrabecular process and/or ala temporalis

abnormal hyoid bone morphology ( J:131382 )

• hyoid in some mutants is fused only unilaterally to basisphenoid bone

• bone typically shows extended ossification center and connects to stapes through a transformed lesser horn

abnormal mandible morphology ( J:131382 )

• at E10.5, apoptosis extending from proximal to distal mandibular region, but is confined to proximal region in wild-type

lower jaw to upper jaw transformation ( J:131382 )

• lower jaw is mirror image of upper jaw with arrays of vibrissae at E18.5

• skeletal analysis shows duplication of upper jaw elements in lower jaw region

Allelic Composition	Ednra^tm1Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm1Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

• animals die at birth

Allelic Composition	Ednra^tm2Hku/Ednra^{tm3(Ednrb)Hku}
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednra^tm2Hku mutation (0 available); any Ednra mutation (35 available)
Ednra^{tm3(Ednrb)Hku} mutation (0 available); any Ednra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:131382 )

craniofacial

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )

skeleton

abnormal craniofacial bone morphology ( J:131382 )

abnormal hyoid bone morphology ( J:131382 )

abnormal mandible morphology ( J:131382 )

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