Analysis Tools
mortality/aging
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• homozygotes survive only until E10.5-11.5 and recapitulate the phenotype of other Myocd null mice
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Allele Symbol Allele Name Allele ID |
Myocdtm1.1Msp targeted mutation 1.1, Michael S Parmacek MGI:3773718 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes survive only until E10.5-11.5 and recapitulate the phenotype of other Myocd null mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• unlike mice homozygous for Myocd tm1.1Msp, mice survive to birth but die by 1 week of age
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• thin bladder wall
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• little or no smooth muscle in the bladder wall
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• grossly dilated bladder at P1
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| N |
• no gross cardiac defects
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• little or no smooth muscle in the bladder wall
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital megabladder | DOID:0112014 |
OMIM:618719 |
J:283803 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die within 1 week of birth
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• in newborns
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• thin bladder wall
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• grossly dilated bladders
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• in newborns
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital megabladder | DOID:0112014 |
OMIM:618719 |
J:283803 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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