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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		E2f8tm1Gle
targeted mutation 1, Gustavo Leone
MGI:3773723
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl3d1tm1(cre)Gle/Prl3d1+ 		involves: 129S6/SvEvTac MGI:5473262
cn2
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Tpbpa-cre,-EGFP)5Jcc/0 		involves: 129S6/SvEvTac MGI:5473263
cn3
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl2c2tm1(cre)Gle/Prl2c2+ 		involves: 129S6/SvEvTac MGI:5473261
cn4
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5473267
cn5
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle 		involves: 129S6/SvEvTac * FVB/N MGI:3797865
cn6
 		E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Cyp19a1-cre)5912Gle/0 		involves: 129S6/SvEvTac * FVB/N MGI:5473266


Genotype
MGI:5473262
cn1
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl3d1tm1(cre)Gle/Prl3d1+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Prl3d1tm1(cre)Gle mutation (0 available); any Prl3d1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5473263
cn2
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5473261
cn3
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Prl2c2tm1(cre)Gle/Prl2c2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Prl2c2tm1(cre)Gle mutation (0 available); any Prl2c2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5473267
cn4
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality ( J:183999 )
• embryos are recovered at every embryonic stage examined, and are born live, but most die within the first postnatal day

embryo
embryo phenotype ( J:183999 )
N
• double mutants with wild-type (Sox2-cre E2f7fl/- E28fl/-) placentas appear normal at E10.5 and lack the developmental phenotypes in double null embryos
• Note: Sox2-cre is expressed only in the inner cell mass with no extraembronic tissue expression so the placentas are normal
• however, embryos rescued from lethality during development die within a few days of birth
abnormal embryonic tissue morphology ( J:183999 )
• significant numbers of apoptotic cells are detected in branchial arches and somites at E10.5

respiratory system
abnormal respiratory system morphology ( J:183999 )
• significant ectopic proliferation and apoptosis of pulmonary cells is observed in lungs at P1, but lungs do not appear overtly hypoplastic




Genotype
MGI:3797865
cn5
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to alkylating agents ( J:131292 )
• MEFs isolated from E13.5 double mutants and infected with a cre recombinase-expressing retrovirus are hypersensitive to DNA damage (camptothecin or cisplatin treatment)




Genotype
MGI:5473266
cn6
Allelic
Composition		 E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Tg(Cyp19a1-cre)5912Gle/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation (0 available); any E2f7 mutation (32 available)
E2f8tm1Gle mutation (0 available); any E2f8 mutation (35 available)
Tg(Cyp19a1-cre)5912Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:183999 )
• no live mutant embryos are recovered after E10.5

growth/size/body
embryonic growth retardation ( J:183999 )
• displayed by live embryos at E10.5

embryo
embryonic growth retardation ( J:183999 )
• displayed by live embryos at E10.5
abnormal embryonic tissue morphology ( J:183999 )
• significant numbers of apoptotic cells are detected in branchial arches at E10.5
abnormal placenta morphology ( J:183999 )
• embryos show collapsed labyrinth-like placental architecture

cardiovascular system
hemorrhage ( J:183999 )
• observed at E10.5 along with vascular dilation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory